| Effects of small intestinal glucose load on blood pressure, splanchnic blood flow, glycaemia and GLP-1 release in healthy older subjects. | |
| | |
MedLine Citation:
|
PMID: 21389332 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Postprandial hypotension (PPH) is an important problem, particularly in the elderly. The fall in blood pressure (BP) is dependent on small intestinal (SI) glucose delivery and, possibly, changes in splanchnic blood flow, the release of glucagon-like peptide-1 (GLP-1) and sympathetic nerve activity. We aimed to determine, in healthy older subjects, the effects of variations in SI glucose load on BP, superior mesenteric artery (SMA) flow, GLP-1 and noradrenaline (NA). Twelve subjects (6M,6F; age 65-76 years) were studied on four separate occasions, in double-blind, randomised order. On each day, subjects were intubated via an anesthetised nostril, with a nasoduodenal catheter, and received an intraduodenal infusion of either saline ('S') (0.9%) or glucose at a rate of 1, 2 or 3 kcal/min ('G1', 'G2', 'G3', respectively), for 60 min (t=0-60 min). Between t=0-60 min, there were falls in systolic and diastolic BP following 'G2' and 'G3' (P=0.003 and P<0.001, respectively), but no change during 'S' or 'G1'. SMA flow increased slightly during 'G1' (P=0.01), and substantially during 'G2' (P<0.001) and 'G3' (P<0.001), but not during 'S'. The GLP-1 response to 'G3' was much greater (P<0.001) than to 'G2' and 'G1'. NA increased (P<0.05) only during 'G3'. In conclusion, in healthy older subjects the duodenal glucose load needs to be greater than 1 kcal/min to elicit a significant fall in BP, while the response may be maximal when the rate is 2 kcal/min. These observations have implications for the therapeutic strategies to manage PPH by modulating gastric emptying. |
| | |
Authors:
|
Lora Vanis; Diana Gentilcore; Christopher K Rayner; Judith M Wishart; Michael Horowitz; Christine Feinle-Bisset; Karen L Jones |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-9 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1University of Adelaide, Royal Adelaide Hospital. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive assessment of vascular structure and function in conscious rats based on in vivo imaging...
Next Document: Rat diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles.