| Effects of small doses of bisoprolol on blood pressure and lipoprotein concentrations in hypertensive patients. | |
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MedLine Citation:
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PMID: 8436149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of bisoprolol 2.5 and 5 mg per day on blood pressure, and lipoprotein and apolipoprotein concentrations were compared in 18 newly detected hypertensives in a double-blind, crossover study. All treatment results were related to the values at the end of a four-week placebo run-in period. Each of the two following treatment periods lasted for 3 months. The systolic and diastolic pressures in the supine position were reduced by 19.5/11.7 mm Hg and 14.6/10.4 mm Hg by 2.5 and 5 mg bisoprolol per day, respectively, with no significant difference in effect. Supine heart rate was reduced by 4.7 and 8.2 beats.min-1, respectively, (P = 0.0517 for different effects). The cholesterol concentration in low-density (LDL) and high-density (HDL) lipoproteins was reduced during both regimens, by about 0.3 and 0.1 mmol.l-1, respectively, difference not significant. Triglyceride concentrations were not significantly affected during either regimen. We conclude that, in this study population, treatment with bisoprolol 2.5 mg per day was equally effective as 5.0 mg per day in reducing blood pressure. The effects on lipoprotein concentrations were small and included an unexpected reduction in LDL-cholesterol concentration. A low dose of a highly selective beta-adrenoceptor blocker like bisoprolol appears to retain the blood pressure reducing capacity and has lost most of the unfavourable effects on lipoproteins characteristic of higher doses. |
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Authors:
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H Lithell; L Weiner; B Vessby; M L Nordström |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 44 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-03-23 Completed Date: 1993-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 19-22 Citation Subset: IM |
Affiliation:
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Institute of Geriatrics, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bisoprolol / administration & dosage*, pharmacology Blood Pressure / drug effects* Cholesterol, HDL / blood Cholesterol, LDL / blood, drug effects Dose-Response Relationship, Drug Double-Blind Method Female Humans Hypertension / blood, drug therapy*, physiopathology Lipoproteins / blood*, drug effects Male Middle Aged Supine Position |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins; 66722-44-9/Bisoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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