Document Detail

Effects of sleeve gastrectomy surgery with modified jejunoileal bypass on body weight, food intake and metabolic hormone levels of rats.
MedLine Citation:
PMID:  22173499     Owner:  NLM     Status:  In-Data-Review    
This study examined the effects of a combined surgery of sleeve gastrectomy (SG) and modified jejunoileal bypass (JIB) on the body weight, food intake, and the plasma levels of active glucagon-like peptide-1 (GLP-1) and total ghrelin of rats. Rats were divided into 3 groups in terms of different surgical protocol: SG-JIB (n=12), SG (n=12), JIB (n=12) and sham surgery groups (n=10). In SG-JIB group, rats was subjected to sleeve gastrectomy and end to side anastomosis of part of the jejunum (25 cm from the ligament of Treitz) to the ileum 25 cm proximal to the cecum. The body weight and food intake were evaluated during 10 consecutive weeks postoperatively. The levels of active GLP-1 and total ghrelin in the plasma of the rats were measured by ELISA assay. The results showed that the SG-JIB treated rats relative to SG- or JIB-treated ones produced a sustained reduction in food intake and weight gain. The level of active GLP-1 was elevated and total ghrelin level decreased in SG-JIB-treated rats as compared with SG- or JIB-treated ones. It was concluded that SG-JIB could efficiently reduce the body weight and food intake, alter obesity-related hormone levels of the rats, indicating that SG-JIB may be potentially used for the treatment of obesity.
Lingling Yan; Zhanyong Zhu; Dan Wu; Qixing Zhou; Yiping Wu
Related Documents :
3934409 - Endoscopic placement of enteral feeding tubes.
22352329 - The feline thyroid gland: a model for endocrine disruption by polybrominated diphenyl e...
11742989 - Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian osc...
14645999 - Independent exponential feeding of glycerol and methanol for fed-batch culture of recom...
9748089 - Time-course studies on plasma glucose, insulin, and cortisol in sea bass (dicentrarchus...
10863409 - Epidemiological study of the risk factors of rampant caries in shanghai children.
4061369 - Chews and swallows and the microstructure of eating.
23605179 - Spices: the savory and beneficial science of pungency.
23261699 - Gold nanoparticles-peptide based gas sensor arrays for the detection of food aromas.
Publication Detail:
Type:  Journal Article     Date:  2011-12-16
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  31     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  784-8     Citation Subset:  IM    
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isoflurane enhances the expression of cytochrome C by facilitation of NMDA receptor in developing ra...
Next Document:  The protective effect of EGB761 on vessels of denervated gastrocnemius in rats and its mechanism.