| Effects of skim milk, skim milk yogurt, orotic acid, and uric acid on lipid metabolism in rats. | |
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MedLine Citation:
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PMID: 15539184 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The effects of feeding two milk products (skim milk and skim milk yogurt) and two proposed hypocholesterolemic factors (orotic acid and uric acid) on serum cholesterol (HDL, LDL, total, HDL/Total and HDL/LDL), liver lipids (total liver lipids and liver cholesterol), and aortal cholesterol were studied. Ten groups, of nine rats each, were fed isocaloric Chow-based diets containing water, 45% skim milk (SM), 45% skim milk yogurt (SMY), and 0.0025% orotic acid (OA) or 0.001% uric acid (UA), without or with cholesterol. The SM diet (with cholesterol) resulted not only in lower total cholesterol (P < 0.10), LDL cholesterol (P < 0.05), aortal cholesterol (P < 0.01), and liver cholesterol (P < 0.10), but also in increased HDL (P < 0.05) and HDL/LDL (P < 0.10) cholesterol ratio. The SMY diet, on the other hand, resulted in lowered total serum cholesterol (P < 0.05) and aortal cholesterol (P < 0.01) and in higher LDL (P < 0.05) cholesterol. The hypocholesterolemic effects were more marked for SM than for SMY. Addition of OA and UA to diets increased serum cholesterol, LDL cholesterol, and total liver lipids; the OA diet also increased liver cholesterol. Neither OA nor UA alone was the factor responsible for the hypocholesterolemic effects seen with SM and SMY feeding. |
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Authors:
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K P Navder; E B Fryer; H C Fryer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 1 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 2004-11-12 Completed Date: 2005-03-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 640-6 Citation Subset: - |
Affiliation:
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Department of Foods and Nutrition, Kansas State University, Manhattan, KS 66506, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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