| Effects of Singulair (montelukast) treatment for capsular contracture. | |
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MedLine Citation:
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PMID: 20601564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Capsular contracture (CC) is one of the most common complications of breast augmentation surgery. Leukotrienes are implicated in the inflammatory cascade and have been postulated to be involved in the formation of CC. Therefore, leukotriene antagonists Accolate and Singulair have been prescribed by plastic surgeons off-label to treat and prevent CC. To date, there are no studies investigating the efficacy of Singulair on CC. OBJECTIVE: The authors retrospectively review a series of patients treated with Singulair to determine whether it improves CC after breast implant surgery. METHODS: Nineteen patients treated with Singulair by the senior surgeon (NH) after implant placement from March 2006 to November 2009 were included in this study. Follow-up on Singulair efficacy was obtained by a combination of office chart review and standardized telephone questionnaire. Results were characterized as complete improvement, improvement, no change, or worse. RESULTS: Seventeen patients presented with CC resulting from a variety of breast operations. Two patients who had a history of recurrent CC were prescribed Singulair prophylactically immediately after surgery. Twenty-one breasts with existing CC were included in the total. Two (11%) patients became worse, three (16%) patients had no change, five (26%) improved, seven (37%) completely improved, and two (11%) were prevented from having CC formation. CONCLUSION: Our preliminary study shows that Singulair improves CC. Breasts with mild CC (Baker score < III) appeared to have better improvement with Singulair compared to those with more severe contracture (Baker score III and IV). Singulair is well tolerated with minimal side effects and can be administered to patients after breast implant surgery to improve CC. |
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Authors:
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Catherine K Huang; Neal Handel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery Volume: 30 ISSN: 1527-330X ISO Abbreviation: Aesthet Surg J Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-26 Revised Date: 2010-12-20 |
Medline Journal Info:
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Nlm Unique ID: 9707469 Medline TA: Aesthet Surg J Country: United States |
Other Details:
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Languages: eng Pagination: 404-8 Citation Subset: IM |
Affiliation:
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Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
/
adverse effects,
pharmacology,
therapeutic use* Adolescent Adult Breast Implantation / adverse effects* Breast Implants / adverse effects Contracture / drug therapy*, etiology Female Follow-Up Studies Humans Leukotriene Antagonists / adverse effects, pharmacology, therapeutic use* Middle Aged Off-Label Use Postoperative Complications / drug therapy Quinolines / adverse effects, pharmacology, therapeutic use* Recurrence Retrospective Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Leukotriene Antagonists; 0/Quinolines; 158966-92-8/montelukast |
| Comments/Corrections | |
Comment In:
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Aesthet Surg J. 2010 May-Jun;30(3):409-10
[PMID:
20601565
]
Aesthet Surg J. 2010 May-Jun;30(3):485-6 [PMID: 20601583 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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