Document Detail


Effects of single intravenous administration of urapidil and diltiazem in patients with nonfixed pulmonary hypertension secondary to chronic obstructive lung disease.
MedLine Citation:
PMID:  7515999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with chronic obstructive lung disease (COLD), pulmonary hypertension (PH) often develops in addition over the course of years. In this study, the acute effects of urapidil and diltiazem in patients with mild PH secondary to COLD were investigated. Eighteen male and 2 female patients, aged 42-78 years, received in randomized, single-blind fashion single intravenous (i.v.) doses of either urapidil (35-50 mg, n = 10) or diltiazem (25 mg, n = 10). Mean pulmonary artery pressure (MPAP), pulmonary wedge pressure (PWP), mean arterial blood pressure (BP) (MAP), and arterial and central venous blood gases were determined at rest and during exercise (starting with 25 W with increases in 25-W steps) before and after drug administration. Urapidil caused a significant reduction in MPAP (from 19 +/- 7 to 15 +/- 4 mm Hg, p < 0.01), PWP (from 9 +/- 3 to 7 +/- 2 mm Hg, p < 0.05), but not significantly in MAP at rest, whereas with diltiazem only MAP was decreased (from 103 +/- 14 to 98 +/- 12 mm Hg, p < 0.05) and MPAP and PWP were not significantly increased.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
F Späh; R Kottman; U Schmidt
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  23     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-08     Completed Date:  1994-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-24     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I (Cardiology), City Hospital, Konstanz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / administration & dosage*,  pharmacology
Adult
Aged
Antihypertensive Agents / administration & dosage*,  pharmacology
Blood Pressure / drug effects
Diltiazem / administration & dosage*,  pharmacology
Female
Humans
Hypertension, Pulmonary / drug therapy*,  etiology
Injections, Intravenous
Lung Diseases, Obstructive / complications*
Male
Middle Aged
Piperazines / administration & dosage*,  pharmacology
Pulmonary Circulation / drug effects
Pulmonary Wedge Pressure / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Antihypertensive Agents; 0/Piperazines; 34661-75-1/urapidil; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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