Document Detail


Effects of a single injection of hCG or GnRH agonist on day 12 post mating on fetal growth and reproductive performance of sheep.
MedLine Citation:
PMID:  15036517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reproductive performance and fetal growth were determined when hCG (150 i.u. Pregnyl; n=44), GnRH (4 microg synthetic GnRH agonist, buserelin, Receptal; n=43) or saline (control, n=45) was administered (i.m.) to ewes on day 12 post mating during the breeding season. A total of 12 ewes was slaughtered on day 45 of pregnancy (four from each treatment group). Non-return rate and lambing rate were higher for ewes in the hCG (0.89 and 84%) and GnRH treated groups (0.86 and 79%) than for ewes in the control (0.69 and 62%) group (P<0.05). The ewes in the hCG and GnRH groups also had more twins (P<0.05). Birth weights of these twin lambs in the hCG and GnRH groups were heavier than those in the control group (P<0.05), but this difference had disappeared at weaning 60 days later. Lamb mortality was similar among treatment groups resulting in a higher number of lambs weaned in the hCG and GnRH groups. The ovarian weights and the number of corpora lutea (CL) and luteal weights of ewes slaughtered on day 45 of pregnancy were greater (P<0.05) in the hCG and GnRH treated groups than those measured in the control group. Administration of hCG on day 12 post mating increased gravid uterus weight, crown-rump-length (CRL), chorioallantois weight and total cotyledon weight (P<0.05) of conceptuses recovered on day 45 of pregnancy compared to the control group. The weights of caruncules (P<0.05) and placenta (P<0.01) were higher in conceptuses of both the hCG and GnRH groups. The weights of fetuses in the hCG group were higher than those in both the GnRH and control groups (P<0.05). In conclusion, both hCG and GnRH administration improved reproductive performance of ewes when administered on day 12 post mating. However, hCG and GnRH appeared to act differently on embryo survival because only hCG administration increased fetal growth.
Authors:
Mehmet Akif Cam; Mehmet Kuran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal reproduction science     Volume:  80     ISSN:  0378-4320     ISO Abbreviation:  Anim. Reprod. Sci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7807205     Medline TA:  Anim Reprod Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  81-90     Citation Subset:  IM    
Affiliation:
Ondokuz Mayis Universitesi, Ziraat Fakultesi, Kurupelit, 55139 Samsun, Turkey. makifcam@omu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Breeding
Buserelin / administration & dosage*
Chorionic Gonadotropin / administration & dosage*
Embryonic and Fetal Development / drug effects*
Female
Fetal Weight / drug effects
Litter Size
Organ Size / drug effects
Placenta / anatomy & histology
Pregnancy
Reproduction / drug effects*
Sheep / physiology*
Weaning
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 57982-77-1/Buserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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