Document Detail

Effects of single dose calcium gluconate infusion in hypocalcemic preterm infants.
MedLine Citation:
PMID:  7710569     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective, double-blind study of 43 preterm infants to examine the effect of a single calcium gluconate infusion as therapy for neonatal hypocalcemia on serum calcium concentrations and hypocalcemic signs in preterm infants with low total serum calcium concentrations. Total and ionized serum calcium was measured and signs of irritability, jitteriness, and twitching were scored (scale 0-9) by blinded observers before and after receiving one dose of either calcium gluconate (100 mg/kg) or placebo (normal saline). Total and ionized serum calcium increased 3 to 6 hours following the calcium, but not the placebo, infusion. Of the infants with hypocalcemic signs, the average score of hypocalcemic signs decreased in the 11 calcium-treated infants; the 12 infants with hypocalcemic signs showed no change of hypocalcemic signs following treatment with placebo. We conclude from this study that a single dose of calcium gluconate (100 mg/kg) in hypocalcemic preterm infants raise total and ionized serum calcium and decrease clinical signs of hypocalcemia.
P J Porcelli; W Oh
Related Documents :
21973909 - Acoustic correlates of stress in spanish infant-directed speech.
17462489 - Evidence supporting early nutritional support with parenteral amino acid infusion.
3382399 - Primapterin, anapterin, and 6-oxo-primapterin, three new 7-substituted pterins identifi...
25119339 - Effects of iron supplements and perinatal factors on fetal hemoglobin disappearance in ...
1155069 - Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
23884719 - Neurodevelopmental outcomes of very low birth weight preterm infants treated with porac...
22393339 - Assessment of primitive reflexes in high-risk newborns.
8620909 - Carriage of multiple ribotypes of non-encapsulated haemophilus influenzae in aboriginal...
19478219 - Predictive value of clinical and eeg features in the diagnosis of stroke and hypoxic is...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of perinatology     Volume:  12     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Women & Infants' Hospital of Rhode Island, Department of Pediatrics, Brown University, Providence 02905-2409, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcium / blood
Calcium Gluconate / administration & dosage,  therapeutic use*
Double-Blind Method
Hypocalcemia / blood,  drug therapy*
Infant, Newborn
Infant, Premature, Diseases / blood,  drug therapy*
Prospective Studies
Time Factors
Grant Support
Reg. No./Substance:
299-28-5/Calcium Gluconate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neonatal hepatitis and excessive hepatic iron deposition following intrauterine blood transfusion.
Next Document:  Erythropoietin use in pregnancy: two cases and a review of the literature.