Document Detail


Effects of single dose calcium gluconate infusion in hypocalcemic preterm infants.
MedLine Citation:
PMID:  7710569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a prospective, double-blind study of 43 preterm infants to examine the effect of a single calcium gluconate infusion as therapy for neonatal hypocalcemia on serum calcium concentrations and hypocalcemic signs in preterm infants with low total serum calcium concentrations. Total and ionized serum calcium was measured and signs of irritability, jitteriness, and twitching were scored (scale 0-9) by blinded observers before and after receiving one dose of either calcium gluconate (100 mg/kg) or placebo (normal saline). Total and ionized serum calcium increased 3 to 6 hours following the calcium, but not the placebo, infusion. Of the infants with hypocalcemic signs, the average score of hypocalcemic signs decreased in the 11 calcium-treated infants; the 12 infants with hypocalcemic signs showed no change of hypocalcemic signs following treatment with placebo. We conclude from this study that a single dose of calcium gluconate (100 mg/kg) in hypocalcemic preterm infants raise total and ionized serum calcium and decrease clinical signs of hypocalcemia.
Authors:
P J Porcelli; W Oh
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of perinatology     Volume:  12     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Affiliation:
Women & Infants' Hospital of Rhode Island, Department of Pediatrics, Brown University, Providence 02905-2409, USA.
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MeSH Terms
Descriptor/Qualifier:
Calcium / blood
Calcium Gluconate / administration & dosage,  therapeutic use*
Double-Blind Method
Female
Humans
Hypocalcemia / blood,  drug therapy*
Infant, Newborn
Infant, Premature, Diseases / blood,  drug therapy*
Male
Prospective Studies
Time Factors
Grant Support
ID/Acronym/Agency:
T32 HD07232-08/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
299-28-5/Calcium Gluconate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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