Document Detail

Effects of single administration of Rokumi-gan (TJ-87) on serum amino acid concentration of 6 healthy Japanese male volunteers.
MedLine Citation:
PMID:  17380019     Owner:  NLM     Status:  MEDLINE    
Rokumi-gan (TJ-87) has beneficial effects on renal diseases, including pollakisuria, dysuria and edema. We previously reported that its long-term administration clinically improved serum protein concentration and edema in renal failure. In this study, we focused on amino acid/protein contents in Rokumi-gan as one of its effectors. Commercially prepared Rokumi-gan contained arginine, aspartate and glutamate at the high levels, alanine, phenylalanine and serine at the moderate levels, and glycine, histidine, isoleucine, leucine, lysine and valine at the low levels. To examine effects of Rokumi-gan on serum amino acid concentrations, 6 healthy Japanese volunteers were treated with commercially prepared Rokumi-gan, an amino acid mixture, and lactose. In subjects treated with an amino acid mixture containing similar amounts of amino acids in Rokumi-gan (10 g), or lactose, serum amounts of many amino acids, except for arginine, gradually and significantly decreased until 6 hr after their treatments. In contrast, a single treatment with Rokumi-gan (10 g) increased serum levels of several amino acids, alanine, arginine, glutamate, glycine and serine. Serum concentrations of almost of all tested amino acids showed the peak value 1-2 hr after administration, and they were sustained at the basal level even 6 hr after the treatment. Our present results suggest that Rokumi-gan may be a beneficial amino acid supplier, because it could sustain serum amino acid concentration at the higher level than an amino acid mixture supplement.
Hideo Takahashi; Reiko Nakao; Katsuya Hirasaka; Kyoichi Kishi; Takeshi Nikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  54     ISSN:  1343-1420     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-23     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
Department of Internal Medicine, The Komatsushima Hospital, Komatsushima, Tokushima, Japan.
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MeSH Terms
Amino Acids / analysis,  blood*
Drugs, Chinese Herbal / chemistry,  pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Drugs, Chinese Herbal; 0/rokumigan

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