| Effects of simvastatin on the number and composition of apoproteinB-containing lipoproteins in hypercholesterolemia: analysis of apoproteinB in each lipoprotein fraction by highly sensitive latex method. | |
| | |
MedLine Citation:
|
PMID: 8980885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the effects of simvastatin on the number and composition of apoproteinB (apoB)-containing lipoproteins in thirteen patients with hypercholesterolemia type IIa or IIb by measuring apoB by a highly sensitive latex method. Patients received simvastatin 5-10 mg (7.7 +/- 0.7 mg, mean +/- SEM) daily for 83-218 days (131 +/- 13 days). In both types of patients, treatment with simvastatin significantly reduced plasma cholesterol levels (mean +/- SEM mg/dl: in type IIa from 234.4 +/- 5.4 to 171.4 +/- 7.8, in type IIb from 242.4 +/- 11.6 to 178.8 +/- 9.6), low density lipoprotein (LDL) cholesterol levels (from 122.6 +/- 5.2 to 68.5 +/- 4.6, and from 115.6 +/- 14.0 to 70.4 +/- 11.6 in the two types, respectively) and LDL apoB levels (from 94.5 +/- 6.6 to 60.6 +/- 7.0, and from 85.0 +/- 8.4 to 56.6 +/- 6.2, respectively). There was no significant change in cholesterol, triglyceride (TG) or apoB in very low density lipoprotein (VLDL). High density lipoprotein (HDL) cholesterol did not change in this study. With respect to lipoprotein composition, the ratio of either cholesterol or TG to apoB in VLDL, intermediate density lipoprotein (IDL) and LDL did not change significantly, but that of TG to apoB in the IDL fraction increased in type IIa. Simvastatin promotes more effective reduction in cholesterol and apoB in LDL than in VLDL, probably by increasing the hepatic LDL receptor which preferentially binds LDL. |
| | |
Authors:
|
K Ikeda Ryomoto; M Suzuki; M Tsushima; A Yamamoto; Y Harano |
Related Documents
:
|
226105 - The effect of cholestyramine on lipoprotein lipids in patients with primary type iia hy... 7240955 - Heterogeneity of serum low density lipoproteins in normal human subjects. 2281925 - The measurement of lipoprotein subfractions in plasma using a tabletop ultracentrifuge. 15721005 - Very low density lipoproteins provide a vector for secretion of paraoxonase-1 from cells. 7733795 - Dietary fibre, what it is and how it is measured. 6375105 - Tiamulin feed premix in the improvement of growth performance of pigs in herds severely... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Endocrine journal Volume: 43 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1997-04-01 Completed Date: 1997-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9313485 Medline TA: Endocr J Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 469-75 Citation Subset: IM |
Affiliation:
|
Department of Atherosclerosis, National Cardiovascular Center, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antilipemic Agents / pharmacology*, therapeutic use Apolipoproteins B / blood*, drug effects Cholesterol / blood Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*, therapeutic use Hypercholesterolemia / blood*, drug therapy Latex Fixation Tests Lipoproteins / blood, chemistry*, classification, drug effects Lovastatin / analogs & derivatives*, pharmacology, therapeutic use Male Middle Aged Sensitivity and Specificity Simvastatin Triglycerides / blood Ultracentrifugation |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Apolipoproteins B; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Untreated Graves' but not remission Graves' immunoglobulin G preparations increase intracellular Ca2...
Next Document: Splenic macrophages can modify steroidogenesis of Leydig cells.