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Effects of silodosin, a selective α 1A -adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis-induced chronic bladder ischemia without bladder outlet obstruction.
MedLine Citation:
PMID:  23545103     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: This study aimed to investigate the effects of silodosin (selective α1A -adrenoceptor antagonist) on bladder blood flow (BBF) and bladder function in a rat model of atherosclerosis-induced chronic bladder ischemia (CBI) without bladder outlet obstruction (BOO). MATERIALS AND METHODS: The CBI model was prepared by balloon endothelial injury of the bilateral iliac arteries in male rats. By means of an osmotic pump, the CBI rats received, subcutaneously, either silodosin at a rate of 0.1 or 0.3 mg/kg/day or vehicle, for 8 weeks. All groups received a 2% cholesterol diet throughout this experiment. For each α1 -adrenoceptor (α1 -AR) subtype mRNA, expression in bladder microvessels was examined by in situ hybridization.BBF was measured using a Laser Speckle Blood Flow Imager. Malondialdehyde in the bladder tissue and 8-hydroxy-2'-deoxyguanosine in the urine were measured as markers of oxidative stress. A metabolic-cage study and cystometry were performed in conscious rats. RESULTS: Expressions of all α1 -AR subtype mRNA were observed in rat bladder microvessels. Silodosin abrogated the decreases in BBF in the empty bladder and during bladder distension that were evident in CBI rats. The levels of oxidative-stress markers present in CBI rats were significantly decreased by silodosin administration. Silodosin ameliorated bladder dysfunction in CBI rats both in the metabolic-cage study and in the cystometric evaluation. CONCLUSIONS: These results suggest that in ischemic conditions, α1A -AR antagonists, such as silodosin, may improve bladder function by restoring BBF.
Authors:
Yoshiaki Goi; Yoshitaka Tomiyama; Masanori Nomiya; Koji Sagawa; Ken Aikawa; Osamu Yamaguchi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-29
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Pharmacology Research Laboratory, Kissei Pharmaceutical Co. Ltd., Azumino City, Japan. Electronic address: yoshiaki_goi@pharm.kissei.co.jp.
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