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Effects of silicate polymers on erythrocytes in presence and absence of complement.
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MedLine Citation:
PMID:  13878239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of silicates upon erythrocytes depend upon the degree of polymerization. Monomeric silicate does not appear to be taken up by red cells. Polymerized silicates are taken up and bound tightly. In the presence of small polymeric forms erythrocytes are lysed by complement. Larger polymers are bound to erythrocytes but do not sensitize to complement hemolysis. Larger polymers, however, are directly toxic and cause hemolysis in the absence of complement. Red cells exposed to complement-active polymers show characteristic alteration in morphology with the assumption of irregular bell shapes. Larger polymers cause the cells to become spherical before spontaneous rupture occurs. Large polymers cause erythrocyte agglutination but this is minimal or absent with small complement-active polymers. Complement-active polymers cause little or no change in osmotic fragility. Increase in mechanical fragility is a sensitive indication of the presence of larger, agglutinating polymers. The conversion of pneumococci from Gram positivity to negativity appears to be caused principally by complement-active polymers. Possible implications of polymer size and complement activity are discussed in relation to production of silicotic lesions by silica-containing ores.
Authors:
P CHARACHE; C M MacLEOD; P WHITE
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  45     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1962 Jul 
Date Detail:
Created Date:  1962-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  1117-43     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Complement System Proteins*
Erythrocytes / pharmacology*
Polymers / pharmacology*
Silicon Dioxide / pharmacology*
Chemical
Reg. No./Substance:
0/Polymers; 7631-86-9/Silicon Dioxide; 9007-36-7/Complement System Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1962, by The Rockefeller Institute Press
Received Day: 16 Month: 1 Year: 1962
Print publication date: Day: 1 Month: 7 Year: 1962
Volume: 45 Issue: 6
First Page: 1117 Last Page: 1143
ID: 2195237
PubMed Id: 13878239

Effects of Silicate Polymers on Erythrocytes in Presence and Absence of Complement
Patricia Charache
Colin M. MacLeod
Peter White
From the Department of Research Medicine, University of Pennsylvania, Philadelphia.
Dr. Charache's present address is Johns Hopkins Hospital, Baltimore. Dr. MacLeod's present address is the Department of Medicine, New York University School of Medicine, New York. Captain White's present address is 5060th United States Air Force Hospital, A.P.O. 731, Seattle, Washington.


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