Document Detail


Effects of sildenafil on the human response to acute hypoxia and exercise.
MedLine Citation:
PMID:  15772499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of the 5-phosphodiesterase (5-PDE) inhibitor sildenafil on pulmonary arterial pressure and some oxygen transport and cardiopulmonary parameters in humans during exposure to hypobaric hypoxia at rest and after exercise. In a double-blind study, 100 mg sildenafil or placebo was administered orally to 14 healthy volunteers 45 min before exposure to 5,000 m of simulated altitude. Arterial oxygen saturation (SaO2), heart rate (HR), tidal volume (VT), respiratory rate (RR), left ventricular ejection fraction (EF), and pulmonary arterial pressure (PAP) were measured first at rest in normoxia, at rest and immediately after exercise during hypoxia, and after exercise in normoxia. The increase in systolic PAP produced by hypoxia was significantly decreased by sildenafil at rest from 40.9 +/- 2.6 to 34.9 +/- 3.0 mmHg (-14.8%; p = 0.0046); after exercise, from 49.0 +/- 3.9 to 42.9 +/- 2.6 mmHg (-12.6%; p = 0.003). No significant changes were found in normoxia either at rest or after exercise. Measurements of the effect of sildenafil on exercise capacity during hypoxia did not provide conclusive data: a slight increase in SaO2 was observed with exercise during hypoxia, and sildenafil did not cause significant changes in ventilatory parameters under any condition. Sildenafil diminishes the pulmonary hypertension induced by acute exposure to hypobaric hypoxia at rest and after exercise. Further studies are needed to determine the benefit from this treatment and to further understand the effects of sildenafil on exercise capacity at altitude.
Authors:
Antoni Ricart; Jaume Maristany; Núria Fort; Conxita Leal; Teresa Pagés; Ginés Viscor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  6     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM; S    
Affiliation:
Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain., Institut d'Estudis de Medicina de Muntanya, Barcelona, Spain. ricart.demesones@retemail.es
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Altitude*
Anoxia / drug therapy*
Blood Pressure / drug effects
Cardiac Output / drug effects
Cross-Over Studies
Double-Blind Method
Exercise*
Exercise Tolerance / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects
Humans
Male
Phosphodiesterase Inhibitors / administration & dosage,  pharmacology*
Piperazines / administration & dosage,  pharmacology*
Pulmonary Artery / drug effects
Pulmonary Circulation / drug effects*
Purines
Reference Values
Sulfones
Tidal Volume / drug effects
Vasodilator Agents / administration & dosage,  pharmacology*
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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