| Effects of sildenafil on exercise capacity in hypoxic normal subjects. | |
| | |
MedLine Citation:
|
PMID: 17584010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sildenafil on echocardiographic indexes of the pulmonary circulation and on cardiopulmonary cycle exercise in normoxia, in acute normobaric hypoxia (fraction of inspired O2, 0.1), and then again after 2 weeks of acclimatization at 5000 m on Mount Chimborazo (Ecuador). In normoxia, sildenafil had no effect on maximum VO2 or O2 saturation. In acute hypoxia, sildenafil increased maximum VO2 from 27 +/- 5 to 32 +/- 6 mL/min/kg and O2 saturation from 62% +/- 6% to 68% +/- 9%. In chronic hypoxia, sildenafil did not affect maximum VO2 or O2 saturation. Resting mean pulmonary artery pressure increased from 16 +/- 3 mmHg in normoxia to 28 +/- 5 mmHg in normobaric hypoxia and 32 +/- 6 mmHg in hypobaric hypoxia. Sildenafil decreased pulmonary vascular resistance by 30% to 50% in these different conditions. We conclude that sildenafil increases exercise capacity in acute normobaric hypoxia and that this is explained by improved arterial oxygenation, rather than by a decrease in right ventricular afterload. |
| | |
Authors:
|
Vitalie Faoro; Michel Lamotte; Gael Deboeck; Adriana Pavelescu; Sandrine Huez; Hervé Guenard; Jean-Benoît Martinot; Robert Naeije |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: High altitude medicine & biology Volume: 8 ISSN: 1527-0297 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-06-22 Completed Date: 2007-09-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 155-63 Citation Subset: IM; S |
Affiliation:
|
Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Altitude* Anoxia / drug therapy* Cross-Over Studies Double-Blind Method Exercise / physiology Exercise Tolerance / drug effects* Female Heart Rate / drug effects Humans Male Middle Aged Phosphodiesterase Inhibitors / pharmacology* Piperazines / pharmacology* Pulmonary Artery / drug effects Pulmonary Circulation / drug effects Purines / pharmacology Reference Values Sulfones / pharmacology* Tidal Volume / drug effects Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Basic life support ventilation in mountain rescue. Official recommendations of the International Com...
Next Document: Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity rel...