Document Detail

Effects of sibutramine on gastric emptying, intestinal motility and rectal tone in dogs.
MedLine Citation:
PMID:  17510801     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the effects of sibutramine on gastric emptying, small-bowel contractions, rectal tone and compliance, and gastrointestinal myoelectrical activity. The study was performed in 14 dogs. It was composed of three separate experiments: gastric emptying of liquids and gastrointestinal slow waves; small-bowel contractions; and rectal tone and rectal compliance. Each experiment included two sessions: a control session and a treatment session with sibutramine (5 mg/kg orally) administrated 2 h before the study. Sibutramine significantly accelerated liquid gastric emptying at 75 and 90 min after the meal but did not alter gastrointestinal slow waves. Gastric emptying at 75 and 90 min was 61.42 +/- 7.71 and 66.32 +/- 7.67% in the control session, and increased to 71.27 +/- 5.14 and 75.93 +/- 5.29% in the session with sibutramine (p < 0.05, vs. control). Sibutramine significantly inhibited postprandial small-bowel contractions. Sibutramine did not alter the rectal tone, but significantly increased rectal compliance. Sibutramine accelerates gastric emptying of liquids but inhibits small-bowel contractions. These findings suggest the peripheral mechanisms of sibutramine in reducing food intake and causing weight loss in obesity patients.
Junying Xu; Jiande Dz Chen
Publication Detail:
Type:  Journal Article     Date:  2007-05-18
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  AIM; IM    
Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555-0632, USA.
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MeSH Terms
Administration, Oral
Appetite Depressants / administration & dosage*
Compliance / drug effects
Cyclobutanes / administration & dosage*
Disease Models, Animal
Gastric Emptying / drug effects*,  physiology
Myoelectric Complex, Migrating / drug effects*,  physiology
Obesity / drug therapy,  physiopathology
Rectum / drug effects,  physiology*
Reg. No./Substance:
0/Appetite Depressants; 0/Cyclobutanes; 106650-56-0/sibutramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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