Document Detail


Effects of short-term training on plasma acid-base balance during incremental exercise in man.
MedLine Citation:
PMID:  12766247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined the effect of short-term submaximal training on plasma acid-base balance during exercise. The influence of water and ion exchange between plasma, active muscles and erythrocytes in the response to training were also studied. The contributions of independent physicochemical variables (i.e. strong ion difference ([SID]), total concentration of weak acids ([Atot]) and PO2) to changes in arterial (a) and femoral venous (v) plasma [H+] were examined in six subjects (age 24+/-1.5 years; maximum oxygen consumption rate (VO2,max), 3.67+/-0.24 l min(-1)) during steady-state cycling for 15 min at each of 30, 65 and 75% of VO2,max before (pre) and after (post) training for 7 days on a cycle ergometer (2 h daily at 60 % VO2,max). The rise in [H+]a during exercise was attenuated post-training by 3 and 5 nequiv l(-1) (P<0.05) at 65 and 75% VO2,max, respectively, due first to less decrease in [SID]a, secondary to lower [Cl-]a and [Lac-]a; and second, to a reduction in [Atot]a, due to greater plasma volume and less plasma water flux (Jv) into leg muscle (P<0.05). The rise in [H+]v was also less in post-training by 4.5 and 6 nequiv l(-1) (P<0.05) at 65 and 75% VO2,max, respectively, and attributed solely to lower [Atot]v (P<0.05). Attenuation of exercise induced decreases in plasma [SID]a and [SID]v from rest to 75 % VO2,max was accompanied by reductions in erythrocyte Lac- and Cl- uptake (P<0.05), and smaller increases in erythrocyte K+ release (P<0.05). We conclude that the training-induced attenuation of the rise in plasma [H+]a and [H+]v during incremental exercise resulted from adaptive changes within muscles (less Lac- production and less water uptake) and erythrocytes (less uptake of Lac-, Cl- and K+), leading to greater [SID] and lower [Atot] in both arterial and femoral venous plasma.
Authors:
Charles T Putman; Norman L Jones; George J F Heigenhauser
Related Documents :
3791707 - Free and conjugated catecholamines in human plasma during physical exercise.
23128667 - Exercise in the community for people with minimal gait impairment due to ms: an assesso...
21411367 - Time kinetics of acute changes in muscle architecture in response to resistance exercise.
10710397 - Heat acclimation improves regulation of plasma volume and plasma na(+) content during e...
1759007 - Cardio-respiratory responses to exercise following treatment of acute severe asthma.
17289447 - The i.v. infusion of mannitol decreases airway responsiveness to methacholine in asthma.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-05-23
Journal Detail:
Title:  The Journal of physiology     Volume:  550     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2004-03-08     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  585-603     Citation Subset:  IM    
Affiliation:
Exercise Biochemistry Laboratory, Faculty of Physical Education, University of Alberta, Edmonton, Canada. tputman@ualberta.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium / physiology*
Adult
Algorithms
Anaerobic Threshold / physiology
Bicycling
Blood Proteins / metabolism
Body Water / physiology
Erythrocyte Volume
Erythrocytes / physiology
Exercise / physiology*
Female
Hematocrit
Hemoglobins / metabolism
Humans
Hydrogen-Ion Concentration
Lactic Acid / blood
Leg / blood supply
Male
Muscle, Skeletal / blood supply,  physiology
Phosphocreatine / blood
Physical Fitness / physiology*
Plasma Volume / physiology
Regional Blood Flow / physiology
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 50-21-5/Lactic Acid; 67-07-2/Phosphocreatine
Comments/Corrections
Comment In:
J Physiol. 2003 Jul 15;550(Pt 2):334   [PMID:  12766238 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Static and dynamic changes in carotid artery diameter in humans during and after strenuous exercise.
Next Document:  Regulation of hyaluronan secretion into rabbit synovial joints in vivo by protein kinase C.