| Effects of short-term training on plasma acid-base balance during incremental exercise in man. | |
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MedLine Citation:
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PMID: 12766247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the effect of short-term submaximal training on plasma acid-base balance during exercise. The influence of water and ion exchange between plasma, active muscles and erythrocytes in the response to training were also studied. The contributions of independent physicochemical variables (i.e. strong ion difference ([SID]), total concentration of weak acids ([Atot]) and PO2) to changes in arterial (a) and femoral venous (v) plasma [H+] were examined in six subjects (age 24+/-1.5 years; maximum oxygen consumption rate (VO2,max), 3.67+/-0.24 l min(-1)) during steady-state cycling for 15 min at each of 30, 65 and 75% of VO2,max before (pre) and after (post) training for 7 days on a cycle ergometer (2 h daily at 60 % VO2,max). The rise in [H+]a during exercise was attenuated post-training by 3 and 5 nequiv l(-1) (P<0.05) at 65 and 75% VO2,max, respectively, due first to less decrease in [SID]a, secondary to lower [Cl-]a and [Lac-]a; and second, to a reduction in [Atot]a, due to greater plasma volume and less plasma water flux (Jv) into leg muscle (P<0.05). The rise in [H+]v was also less in post-training by 4.5 and 6 nequiv l(-1) (P<0.05) at 65 and 75% VO2,max, respectively, and attributed solely to lower [Atot]v (P<0.05). Attenuation of exercise induced decreases in plasma [SID]a and [SID]v from rest to 75 % VO2,max was accompanied by reductions in erythrocyte Lac- and Cl- uptake (P<0.05), and smaller increases in erythrocyte K+ release (P<0.05). We conclude that the training-induced attenuation of the rise in plasma [H+]a and [H+]v during incremental exercise resulted from adaptive changes within muscles (less Lac- production and less water uptake) and erythrocytes (less uptake of Lac-, Cl- and K+), leading to greater [SID] and lower [Atot] in both arterial and femoral venous plasma. |
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Authors:
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Charles T Putman; Norman L Jones; George J F Heigenhauser |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-05-23 |
Journal Detail:
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Title: The Journal of physiology Volume: 550 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2004-03-08 Revised Date: 2013-06-09 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 585-603 Citation Subset: IM |
Affiliation:
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Exercise Biochemistry Laboratory, Faculty of Physical Education, University of Alberta, Edmonton, Canada. tputman@ualberta.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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physiology* Adult Algorithms Anaerobic Threshold / physiology Bicycling Blood Proteins / metabolism Body Water / physiology Erythrocyte Volume Erythrocytes / physiology Exercise / physiology* Female Hematocrit Hemoglobins / metabolism Humans Hydrogen-Ion Concentration Lactic Acid / blood Leg / blood supply Male Muscle, Skeletal / blood supply, physiology Phosphocreatine / blood Physical Fitness / physiology* Plasma Volume / physiology Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Hemoglobins; 50-21-5/Lactic Acid; 67-07-2/Phosphocreatine |
| Comments/Corrections | |
Comment In:
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J Physiol. 2003 Jul 15;550(Pt 2):334
[PMID:
12766238
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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