| Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. | |
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MedLine Citation:
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PMID: 20483648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The present study aimed to assess the effects of excess fat, fructose and fat-plus-fructose intakes on intrahepatocellular lipid (IHCL). METHODS: Healthy male subjects were studied after an isocaloric diet or a 7-day high-fructose (Fru: +3.5 g fructose/kg fat-free mass/day, +35% energy), high-fat (Fat: +30% energy as saturated-fat) or high-fructose, high-fat diet (FruFat: +3.5 g fructose/kg fat-free mass/day, +30% energy as fat, +65% total energy). IHCL was measured by (1)H magnetic resonance spectroscopy. RESULTS: All hypercaloric diets increased IHCL (Fru: +16%; Fat: +86%; FruFat: +133%; P<0.05). Very low-density lipoprotein (VLDL) triacylglycerols increased after Fru (+58%; P<0.05), but decreased after Fat (-22%; P<0.05), while no change was observed after FruFat. CONCLUSION: Fat and fructose both increased IHCL, but fructose increased, while fat decreased, VLDL triacylglycerols. However, excess fat and fructose combined had additive effects on IHCL and neutralizing effects on VLDL triglycerides. This suggests that fructose stimulates, while fat inhibits, hepatic VLDL triacylglycerol secretion. |
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Authors:
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H Sobrecases; K-A Lê; M Bortolotti; P Schneiter; M Ith; R Kreis; C Boesch; L Tappy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-18 |
Journal Detail:
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Title: Diabetes & metabolism Volume: 36 ISSN: 1878-1780 ISO Abbreviation: Diabetes Metab. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607599 Medline TA: Diabetes Metab Country: France |
Other Details:
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Languages: eng Pagination: 244-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 7, rue du Bugnon, 1005 Lausanne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Glucose / metabolism Diet* Dietary Fats / administration & dosage*, metabolism Fatty Liver / metabolism* Fructose / administration & dosage*, metabolism Glucose / metabolism Humans Hyperphagia / blood, metabolism Lipoproteins, VLDL / blood*, metabolism Liver / metabolism Magnetic Resonance Spectroscopy Male Triglycerides / blood*, metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats; 0/Lipoproteins, VLDL; 0/Triglycerides; 30237-26-4/Fructose; 50-99-7/Glucose |
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