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Effects of short term mild L-Thyroxine suppression therapy on myocardial functions, and its assessment with tissue Doppler imaging.
MedLine Citation:
PMID:  25389951     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: While adverse effects of overt hyperthyroidism on the cardiovascular system are well--known, the effects of subclinical hyperthyroidism are not clear. Here, we aimed to investigate the effects of short term mild L--thyroxine (LT4) suppression therapy on myocardial functions in a group of premenopausal women with goiter, by using echocardiographic methods and tissue Doppler imaging (TDI).
MATERIALS AND METHODS: Sixteen participants with goiter received LT4 suppression therapy to keep TSH levels between 0.1--0.4 μIU/mL. After baseline and 1st month assessment, 6--week follow--ups were scheduled until 6th month assessment to adjust the medication dose during study period. All TSH levels decreased below 0.4 μIU/mL by the end of first month and stayed below this level throughout study period. At the beginning of the study and at month 6, the thyroid ultrasonography, Holter monitorization test, stress test, electrocardiograms and echocardiograms of participants were assessed. This was followed by a comparison of baseline and 6th month data.
RESULTS: Baseline and 6th month 2--D echocardiography measurements of participants revealed that mean left ventricle diameter in diastole (4.1±0.3 vs 3.8±0.2) and posterior wall thickness in diastole (0.9±0.1 vs. 0.8±0.1) decreased (p<0.05); while stroke volume (41.9±9.9 vs. 48±8.2), stroke volume index (25.6±5.4 vs. 29.4±4.7), cardiac output (3.5±1.4 vs. 3.9±0.9) and cardiac index (2.2±0.8 vs. 2.4±0.5) increased (p<0.05). Other 2D echocardiography parameters did not change significantly. The pulse wave Doppler examination, stress test and Holter monitorization of participants did not reveal any difference between baseline and 6th month measurements. No statistically significant difference was observed in measurements of TDI except decreased septum S velocity.
CONCLUSION: Short term mild LT4 suppression treatment did not cause systolic or diastolic dysfunction, or conduction defect in the heart; and therefore may be safe in premenopausal females with no known cardiac disease.
Authors:
Y Bozkuş; A Sünger; A Yıldırır; N Bascil Tütüncü
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-12
Journal Detail:
Title:  Minerva endocrinologica     Volume:  -     ISSN:  0391-1977     ISO Abbreviation:  Minerva Endocrinol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-12     Completed Date:  -     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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