Document Detail


Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome.
MedLine Citation:
PMID:  16716324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this retrospective study was to compare the frequency of menstrual cyclicity between two groups of patients with polycystic ovary syndrome: women who were followed while on metformin for 3-6 months and those who were followed for >6 months. The results showed that metformin is highly effective in normalizing menstrual cyclicity in women with polycystic ovary syndrome (the overall response rate was 69%, with 88% of responders achieving normal cyclicity), especially with a treatment duration of 6 months or longer (the response rate was 40% higher for women who were treated with metformin for >6 months vs. 3-6 months, 77% vs. 55%).
Authors:
Paulina A Essah; Teimuraz Apridonidze; Maria J Iuorno; John E Nestler
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-05-23
Journal Detail:
Title:  Fertility and sterility     Volume:  86     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-2     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0111, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Hyperinsulinism / prevention & control*
Hypoglycemic Agents / administration & dosage
Longitudinal Studies
Menstrual Cycle / drug effects*
Metformin / administration & dosage*
Polycystic Ovary Syndrome / drug therapy*
Retrospective Studies
Time Factors
Treatment Outcome
Women
Grant Support
ID/Acronym/Agency:
2R01HD35629-06/HD/NICHD NIH HHS; K12DA14041-03/DA/NIDA NIH HHS; K24HD40237/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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