Document Detail

Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma.
MedLine Citation:
PMID:  10738706     Owner:  NLM     Status:  MEDLINE    
To gain further insight into the kinetics of airway inflammatory response and explore the possibility of nitric oxide as a surrogate marker of the lower airway inflammatory response to ozone, nine subjects with mild atopic asthma were exposed to filtered air or 0.2 ppm ozone for 2 hours with intermittent exercise. Lung function was measured at baseline and immediately after exposures. Sputum induction was performed at 6 hours and at 24 hours after exposures, and exhaled nitric oxide levels were measured at baseline, immediately, 6, and 24 hours after both exposures. A significant decline in forced expiratory volume in one second and inspiratory capacity was detectable following exposure to ozone. In addition, a 2-fold increase was observed in the percentage of polymorphonuclear leukocytes 6 hours after exposure to ozone, with no changes in other biomarkers at this time point. By 24 hours after ozone exposure, the neutrophilia had subsided but there was an increase in albumin, total protein, myeloperoxidase, and eosinophil cationic protein. Exhaled nitric oxide levels, histamine, interleukin-8, and growth-related oncogene-alpha in sputum did not change significantly following ozone exposure. It was concluded that short-term ozone exposure induces an acute inflammatory response in asthmatic airways, characterized by early polymorphonuclear leukocyte influx followed by plasma extravasation and activation of eosinophils and neutrophils. Exhaled nitric oxide is not a useful marker for detecting inflammatory response to ozone in persons with mild asthma.
E J Newson; M T Krishna; L C Lau; P H Howarth; S T Holgate; A J Frew
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  42     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-14     Completed Date:  2000-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
Southampton General Hospital, United Kingdom.
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MeSH Terms
Administration, Inhalation
Asthma / diagnosis*,  etiology*
Biological Markers / analysis*
Environmental Exposure / adverse effects*,  analysis
Inflammation Mediators / analysis*
Nitric Oxide / analysis*,  metabolism
Ozone / administration & dosage,  adverse effects*
Reference Values
Respiratory Function Tests
Sensitivity and Specificity
Sputum / chemistry*,  cytology
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 10028-15-6/Ozone; 10102-43-9/Nitric Oxide

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