Document Detail

Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults.
MedLine Citation:
PMID:  23174856     Owner:  NLM     Status:  Publisher    
Dietary nitrate (NO(3)(-)) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effects might also be evident in older adults. In a double-blind, randomized, crossover study, twelve healthy, older (60-70 yrs) adults supplemented their diet for three days with either nitrate-rich concentrated beetroot juice (BR; 2 x 70 ml•d(-1), ~9.6 mmol•d(-1) NO(3)(-)) or a nitrate-depleted beetroot juice placebo (PL; 2 x70 ml•d(-1), ~0.01 mmol•d(-1) NO(3)(-)). Before and after the intervention periods, resting blood pressure and plasma [nitrite] were measured and subjects completed a battery of physiological and cognitive tests. Nitrate supplementation significantly increased plasma [nitrite] and reduced resting systolic (BR:115 ± 9 vs. PL:120 ± 6 mmHg; P<0.05) and diastolic (BR:70 ± 5 vs. PL:73 ± 5 mmHg; P<0.05) blood pressure. Nitrate supplementation resulted in a speeding of the VO(2) mean response time (BR:25 ± 7 vs. PL:28 ± 7 s; P<0.05) in the transition from standing rest to treadmill walking, although the O(2) cost of exercise remained unchanged. Functional capacity (6 minute walk test), the muscle metabolic response to low-intensity exercise, brain metabolite concentrations and cognitive function were not altered. Dietary nitrate supplementation reduced resting blood pressure and positively modulated the VO(2) response to walking exercise in healthy older adults but did not improve walking performance. These results may have implications for the enhancement of cardiovascular health in older age.
James Kelly; Jonathan Fulford; Anni Vanhatalo; Jamie R Blackwell; Olivia French; Stephen J Bailey; Mark Gilchrist; Paul G Winyard; Andrew M Jones
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Exeter University.
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