Document Detail

Effects of short-chain galacto- and long-chain fructo-oligosaccharides on systemic and local immune status during pregnancy.
MedLine Citation:
PMID:  22464279     Owner:  NLM     Status:  Publisher    
Nondigestible oligosaccharides can positively influence health via various mechanisms. During pregnancy, supplementation of nondigestible oligosaccharides has positive effects on hypertension and metabolism and may be used to ameliorate pregnancy-related metabolic disturbances. In the nonpregnant state, nondigestible oligosaccharides have been shown to induce a tolerogenic immune response mediated by T-regulatory cells. Since relatively little is known about the effects of nondigestible oligosaccharides on the immune system during pregnancy, pregnant mice were supplemented with a specific mixture of short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS; ratio 9:1). Systemic and local immune parameters were analyzed on day 18 of pregnancy. This study shows that, compared with virgin mice, scGOS/lcFOS supplementation appears to elicit a more tolerogenic immune reaction in pregnant mice and supplementation does not increase the Th1-dependent delayed type hypersensitivity response in pregnant mice as it does in virgin mice.
N van Vlies; A Hogenkamp; S Thijssen; G M Dingjan; K Knipping; J Garssen; L M J Knippels
Related Documents :
16157119 - Chronic villitis in untreated neonatal alloimmune thrombocytopenia: an etiology for sev...
16645579 - Risk factors for neonatal tetanus--busoga region, uganda, 2002-2003.
9057379 - Fluconazole in the management of neonatal systemic candidiasis.
23630149 - Vaginal delivery through annular placenta - case report.
24722709 - Adenomyosis in pregnancy mimicking morbidly adherent placenta.
603799 - Noradrenaline appearance in guinea pig brown adipose tissue. its significance in neonat...
3276379 - Anthracyclines in the treatment of malignancy in pregnancy.
2774679 - Placental characteristics in twin transfusion syndrome.
25004309 - Majocchi granuloma in a pregnant woman.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  -     ISSN:  1872-7603     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bone-seeking TRAP conjugates: surprising observations and their implications on the development of g...
Next Document:  The salience of existential concerns across the cancer control continuum.