Document Detail

Effects of short-chain fatty acids on human rectosigmoid mucosal colonocyte brush-border enzymes.
MedLine Citation:
PMID:  9472958     Owner:  NLM     Status:  MEDLINE    
Short-chain fatty acids produced by bacterial fermentation of dietary fiber may provide a tonic stimulus to colonocyte differentiation that contributes to the protective effect of fiber against colorectal malignancy. Since brush-border enzymes are common markers of colonocytic differentiation, we compared the effects of equimolar (10 mmol/L) concentrations of the three most common short-chain fatty acids, acetate, butyrate, and propionate, on the alkaline phosphatase and dipeptidyl dipeptidase specific activity of human colonic mucosal biopsies obtained from normal volunteers. Only butyrate significantly stimulated alkaline phosphatase specific activity (50.4% +/- 18.6%, P < .05). Short-chain fatty acid stimulation of dipeptidyl dipeptidase did not achieve statistical significance. Fibers yielding high colonic butyrate levels could have different effects on human colonic mucosal differentiation.
M D Basson; S A Sgambati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  47     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-4     Citation Subset:  IM    
Department of Surgery, Yale University, New Haven, CT 06520-8062, USA.
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MeSH Terms
Alkaline Phosphatase / metabolism
Colon / drug effects*,  enzymology,  ultrastructure
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism
Fatty Acids / pharmacology*
Intestinal Mucosa / drug effects,  enzymology
Microvilli / drug effects,  enzymology
Reg. No./Substance:
0/Fatty Acids; EC Phosphatase; EC 3.4.14.-/Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

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