Document Detail


Effects of sex steroid hormones, thyroid hormone levels, and insulin regulation on thyrotoxic periodic paralysis in Chinese men.
MedLine Citation:
PMID:  20972724     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Our study is to determine the expression of thyroid hormone, sex hormone, insulin, and C-peptide in Chinese male patients with thyrotoxic periodic paralysis (TPP). This study covered 102 patients with hyperthyroidism from Xijing Hospital. According to whether occurrence of TPP or not, patients were divided into two groups (those that were hyperthyroid with and without TPP) that were, matched with age, blood pressure, urea, and creatinine. We found the body mass index (BMI) in patients with TPP was higher than that in pure hyperthyroidism patients. The levels of the total thyroxine (T4), free triiodothyronine (FT3), and free thyroxine (FT4) were significantly lower in patients with TPP compared with pure hyperthyroidism patients, while serum testosterone levels were higher compared with pure hyperthyroidism patients. Moreover, after glucose administration, the concentration of insulin at 60, 120, and 180 min were significantly higher in patients with TPP than those in pure hyperthyroidism patients. The insulin area under the curve (AUC) was significantly increased in patients with TPP compared with pure hyperthyroidism patients. The levels of thyroid hormone, sex hormone, and insulin were different in Chinese male patients with TPP compared to those with only hyperthyroidism.
Authors:
Wang Li; Chen Changsheng; Fu Jiangfang; Gao Bin; Zhang Nanyan; Li Xiaomiao; Li Deqiang; Xing Ying; Zai Wensong; Ji Qiuhe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-23
Journal Detail:
Title:  Endocrine     Volume:  38     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  386-90     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism, Xijing Hospital, The Fourth Military Medical University, Xi'an Shaanxi 710032, China.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R24 TW007988/TW/FIC NIH HHS

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