Document Detail

Effects of sex and age on strength-duration properties.
MedLine Citation:
PMID:  16875875     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the possible effects of sex and age on strength-duration time constant (SDTC). METHODS: The SDTC of 126 healthy volunteers was measured following stimulation of right median nerve at the wrist. Variations in values were evaluated according to sex and age. RESULTS: The SDTC was 438.6+/-114.5 micros in women and 396.2+/-90.3 in men (P=.023). In men, as age increased, so did SDTC. However, this was not true in women. Comparing the values of women and men, aged below 40, demonstrated a difference in excitability, confined to younger patients. CONCLUSIONS: As SDTC depends on the biophysical properties of the axonal membrane and can provide some information about Na(+) channel function, these data raise the possibility of a difference in Na(+) channel function between men and women and a difference in the conductance with age. SIGNIFICANCE: The age- and sex-related differences shown in this study suggest a possible biochemical or hormonal influence on axonal excitability.
Deniz Yerdelen; Hilmi Uysal; Filiz Koc; Yakup Sarica
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-07-27
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  117     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-11-28     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2069-72     Citation Subset:  IM    
Department of Neurology, Cukurova University Medical School, Adana, Turkey.
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MeSH Terms
Action Potentials / physiology*,  radiation effects
Aged, 80 and over
Aging / physiology*
Dose-Response Relationship, Radiation
Electric Stimulation / methods
Median Nerve / physiology
Middle Aged
Neural Conduction / physiology,  radiation effects
Reaction Time / physiology*,  radiation effects
Sex Characteristics*
Wrist / innervation,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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