Document Detail

Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice.
MedLine Citation:
PMID:  10488957     Owner:  NLM     Status:  MEDLINE    
Estrogens and immunity against LDL could be important in atherogenesis. Herein, we describe the development of atherosclerotic lesions and cellular immune responses to modified LDL in male and female apoE knockout (E0) mice over time, and the effect of 17beta-estradiol on atherosclerosis-related cellular immunity. Animals were studied after 16 or 48 weeks of normocholesterol diet. Aortic lesions, lymphocyte populations, and the cellular immune response against modified LDL, with or without 17beta-estradiol, were analyzed. Atherosclerotic lesions were larger and more advanced in young female than in male E0 mice. In older mice, no significant difference in lesion size or maturity was discerned between males and females. In spleen cell cultures of young females, addition of 17beta-estradiol induced a proliferative T-cell response to oxidized LDL, while no such effect was seen in males. In similar cultures from old E0 mice, T-cells from female animals were activated by oxidized LDL even in the absence of exogenous estrogens. These data show important sex differences in the development of atherosclerosis. They suggest that these differences may be related to sex differences in the cellular immune responses to the atherosclerosis-related autoantigen, oxidized LDL.
G Caligiuri; A Nicoletti; X Zhou; I Törnberg; G K Hansson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  145     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-13     Completed Date:  1999-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Age Factors
Aorta, Thoracic / pathology
Apolipoproteins E / deficiency*
Arteriosclerosis / immunology*,  pathology
Autoantigens / immunology
Autoimmunity / immunology*
Cell Division
Cells, Cultured
Disease Models, Animal
Estradiol / pharmacology
Immunity, Cellular
Lipoproteins, LDL / immunology,  pharmacology
Lymphocyte Activation / drug effects
Mice, Inbred C57BL
Mice, Knockout
Sex Factors
Spleen / immunology
T-Lymphocytes / drug effects,  immunology
Reg. No./Substance:
0/Apolipoproteins E; 0/Autoantigens; 0/Lipoproteins, LDL; 50-28-2/Estradiol

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