Document Detail

Effects of sevoflurane on postoperative liver functions in morbidly obese as compared to the non-obese patients.
MedLine Citation:
PMID:  19583067     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of sevoflurane anesthesia on hepatic function in morbidly obese versus non-obese patients undergoing abdominal surgeries.
METHODS: We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan. Measurement of liver enzymes was done in the recovery room, and on the first, 3 and 7 days after sevoflurane anesthesia, and the results were compared between the morbidly obese and non obese patients.
RESULTS: ALT, AST, GGT and LDH increased significantly in the morbidly obese than they did in non obese patients. In morbidly obese patients TBil increased gradually peaking 7 days after anesthesia, LDH increased in the recovery room, AST and ALT increased in the recovery room and first day, while GGT increased 7th day after anesthesia. In non obese patients, AST, LDH increased in the recovery. ALP did not change in both groups.
CONCLUSION: Sevoflurane induces elevation of the serum liver enzymes in morbidly obese patients with variable onsets.
Subhi M Al-Ghanem; Islam M Massad; Bassam Al-Barazangi; Mahmoud Al-Mustafa; Fayez S Daoud; Hamdi Abu-Ali
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  20     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-08-04     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM    
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MeSH Terms
Abdomen / surgery
Anesthetics, Inhalation / adverse effects*,  therapeutic use
Hospitals, University
Liver / drug effects*,  metabolism
Liver Function Tests
Methyl Ethers / adverse effects*,  therapeutic use
Middle Aged
Obesity, Morbid / complications*
Postoperative Complications / chemically induced
Prospective Studies
Time Factors
Young Adult
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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