Document Detail

Effects of sevoflurane and isoflurane on systemic vascular resistance: use of cardiopulmonary bypass as a study model.
MedLine Citation:
PMID:  8672388     Owner:  NLM     Status:  MEDLINE    
We have examined the dose-related effects of sevoflurane and isoflurane on systemic vascular resistance (SVR) during cardiopulmonary bypass (CPB) in patients undergoing elective coronary artery surgery. Fifty-two patients were allocated randomly to one of six groups to receive 1.0, 2.0 or 3.0 vol% (inspiratory) sevoflurane or 0.6, 1.2 or 1.8 vol% isoflurane, or to a control group. During hypothermic (32-33 degrees C) non-pulsatile CPB, systemic vascular resistance index (SVRI) was recorded before administration of volatile anaesthetics and every 5 min for 20 min. Sevoflurane and isoflurane concentrations were measured next to the gas inlet port and at the gas outlet port of the oxygenator. Wash-in of sevoflurane occurred more rapidly than that of isoflurane, reaching a relatively steady state for both agents from the 10th to the 20th min. There was no significant change in SVRI in patients receiving 1.0 and 2.0 vol% sevoflurane, and 0.6 and 1.2 vol% isoflurane, compared with baseline values. However, 3 vol% sevoflurane decreased SVRI at 10, 15 and 20 min, and 1.8 vol% isoflurane decreased SVRI significantly at 15 and 20 min, whereas SVRI increased at 15 and 20 min in the control group. Thus during CPB, sevoflurane had similar vasodilator effects on SVRI as isoflurane.
G Rödig; C Keyl; G Wiesner; A Philipp; J Hobbhahn
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  76     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-08-12     Completed Date:  1996-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Department of Anaesthesiology, University Hospital, Regensburg, Germany.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage*
Cardiopulmonary Bypass*
Dose-Response Relationship, Drug
Ethers / administration & dosage*
Isoflurane / administration & dosage*
Middle Aged
Time Factors
Vascular Resistance / drug effects*
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ethers; 0/Vasodilator Agents; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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