Document Detail

Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets.
MedLine Citation:
PMID:  11103187     Owner:  NLM     Status:  MEDLINE    
In vitro, halogenated agents reduce the pulmonary vasoconstrictor response to alveolar hypoxia in isolated perfused lungs. However, studies in intact animals have been less convincing. The aim of the present study was to assess the effect of sevoflurane on hypoxic pulmonary vasoconstriction (HPV) in anaesthetized piglets using the pressure/cardiac index relationship (P/Q). Ten large white piglets were anaesthetized and mechanically ventilated, alternately in hyperoxia (FIO2 = 0.4) and hypoxia (FIO2 = 0.12). Multipoint plots of pulmonary arterial pressure (PAP) or differences between PAP and left atrial pressure (LAP) against Q were generated by gradual inflation of a balloon introduced into the inferior vena cava. P/Q relationships were established in hyperoxia and hypoxia at baseline, and then with sevoflurane. In hypoxia, pressure gradients (PAP-LAP) increased at every level of Q, thus demonstrating active pulmonary vasoconstriction. Sevoflurane at 1 MAC did not affect these P/Q relationships in hyperoxia or hypoxia as compared with baseline. Sevoflurane at a clinically relevant concentration (1 MAC) has no significant effect on HPV in anaesthetized piglets.
F Kerbaul; M Bellezza; C Guidon; L Roussel; M Imbert; J P Carpentier; J P Auffray
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  440-5     Citation Subset:  IM    
Département d'Anesthésie-Réanimation Adulte, Groupe Hospitalier de La Timone, Marseille, France.
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MeSH Terms
Anesthesia, Inhalation / adverse effects
Anesthetics, Inhalation / pharmacology*
Anoxia / physiopathology*
Blood Pressure / drug effects
Carbon Dioxide / blood
Hydrogen / blood
Hydrogen-Ion Concentration
Hyperoxia / physiopathology
Least-Squares Analysis
Methyl Ethers / pharmacology*
Pulmonary Circulation / drug effects*
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 1333-74-0/Hydrogen; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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