Document Detail

Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder.
MedLine Citation:
PMID:  12955289     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD). OBJECTIVES: Our aim was to investigate changes of hand-motor dysfunction in OCD patients under the influence of 10-week treatment with sertraline and behaviour therapy. METHODS: We examined the performance of 40 patients satisfying DSM-IV criteria for OCD before and under this therapy using a digitising tablet and kinematic analysis of handwriting and drawing movements. Forty healthy controls were also tested (test-retest interval: 10 weeks). RESULTS: The speed of drawing was significantly lower in OCD patients than in controls (mean+/-standard deviation=197.03+/-113.26 mm/s for patients and 182.48+/-189.61 mm/s for controls; P=0.01). After 10 weeks of therapy, this parameter normalised in patients (from 197.03+/-113.26 mm/s to 163.66+/-101.92 mm/s; P=0.001). CONCLUSIONS: Hand-motor dysfunction (especially bradykinesia) improves with a serotonin-enhancing therapy in OCD patients.
Roland Mergl; Paraskevi Mavrogiorgou; Georg Juckel; Michael Zaudig; Ulrich Hegerl
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-30
Journal Detail:
Title:  Psychopharmacology     Volume:  171     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-23     Completed Date:  2004-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig-Maximilians-Universität München, Nussbaumstrasse 7, 80336, München, Germany.
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MeSH Terms
Hand / physiopathology*
Motor Skills Disorders / drug therapy,  physiopathology
Movement / drug effects*
Movement Disorders / drug therapy*,  physiopathology
Obsessive-Compulsive Disorder / drug therapy*,  physiopathology,  psychology
Serotonin Uptake Inhibitors / therapeutic use*
Sertraline / therapeutic use*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 79617-96-2/Sertraline

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