Document Detail

Effects of serotonin and noradrenaline on superficial hand veins in patients with primary hypertension and in healthy volunteers.
MedLine Citation:
PMID:  1470220     Owner:  NLM     Status:  MEDLINE    
In vitro and animal experiments suggest that a constitutional increase in vascular responsiveness to serotonin (5-HT) may play a role in the development of essential hypertension. We have studied the potential alterations in vascular responsiveness to the direct and catecholamine-potentiating effects of exogenous 5-HT in patients with essential hypertension, by comparing in vivo responsiveness of superficial hand veins to local infusions of 5-HT or to coinfusions of 5-HT and noradrenaline in unmedicated hypertensive patients and in healthy control subjects. The dorsal hand vein compliance technique was employed. There was no significant difference between patients and control subjects in the maximal 5-HT-induced venoconstriction or in the doses required for half-maximal venoconstriction (ED50) for 5-HT. Coinfusions of a constant dose of 5-HT caused a significant leftward shift in the dose response curve for noradrenaline as compared with noradrenaline alone. This was indicated by a 9.7 +/- 13.7 fold and a 10.4 +/- 13.8 fold increase in the ED50 for noradrenaline in the patient and control groups, respectively (p = 0.89 between study groups). Our results argue against a generalized increase in responsiveness to the direct or catecholamine-potentiating effect of 5-HT in vivo in vascular smooth muscle, associated with hypertension.
M Wolzt; E Schmidt; B Wagner; S Schuller-Petrovic; P A Kyrle; H G Eichler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  346     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-27     Completed Date:  1993-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  IM    
Department of Clinical Pharmacology, Vienna University Hospital, Austria.
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MeSH Terms
Dose-Response Relationship, Drug
Hand / blood supply*
Hypertension / physiopathology*
Middle Aged
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology*
Regional Blood Flow / drug effects
Serotonin / adverse effects,  pharmacology*
Vasoconstriction / drug effects
Veins / drug effects
Reg. No./Substance:
50-67-9/Serotonin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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