Document Detail

Effects of selenium supplementation on hepatocarcinogenesis in rats.
MedLine Citation:
PMID:  4070005     Owner:  NLM     Status:  MEDLINE    
Four groups of weanling male Wistar rats (Groups A-D) received diethylnitrosamine (DEN, 40 ppm) in their drinking water for four weeks; after a recovery period of two weeks, they received (for the rest of the experiment) phenobarbital (PB, 500 ppm) added to a Torula yeast-based diet containing 0.17 ppm of selenium. Dietary selenium (2 ppm), as sodium selenite, was given to Group B one week before and during DEN treatment, to Group C one week before and during PB treatment, and to Group D during the entire experiment. Groups A and E received the unsupplemented diet, whereas Group E was not treated with DEN or PB. Pair-feeding conditions were used to minimize possible influences of differences in food intake and growth. Rats were killed at the 19th and 24th weeks after the experiment began. No significant differences were found in food and fluid intakes or in growth rates among the groups. Livers in Group E were histologically normal, whereas preneoplastic and neoplastic lesions were found in all other groups. In rats killed at the 19th and 24th weeks, the numerical and the volumetric densities of preneoplastic lesions did not differ significantly between all the groups. Similarly, the incidence of hepatocellular carcinomas only detected at 24 weeks was not significantly different between the groups. These results indicated that in this particular model of hepatocarcinogenesis, the dietary supplementation of 2 ppm of selenium did not modify the development of preneoplasia and carcinomas.
T M Aquino; E A Porta; H M Sablan; R D Dorado
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  7     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-03     Completed Date:  1986-01-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-36     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Liver / pathology
Liver Neoplasms, Experimental / chemically induced,  pathology,  prevention & control*
Organ Size / drug effects
Precancerous Conditions / pathology,  prevention & control
Rats, Inbred Strains
Selenious Acid
Selenium / administration & dosage*
Grant Support
Reg. No./Substance:
50-06-6/Phenobarbital; 55-80-1/Methyldimethylaminoazobenzene; 7782-49-2/Selenium; 7783-00-8/Selenious Acid

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