Document Detail

Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.
MedLine Citation:
PMID:  12475444     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To study the effect of selenium (Se) and iodine (I) and the compound of both on the proto-oncogenes c-fos and c-jun mRNA and their protein expression in the cultured rat hippocampus neurons.
METHODS: Using the technique of serum free hippocampus neuron culture, different doses of Se and I and Se + I compound were added into the medium. The expression of the mRNA of c-fos, c-jun in hippocampus neurons cultured for 1, 3, 5, 7 and 10 d were studied using both in situ hybridization and SABC immunohistochemical technique.
RESULTS: Both Se and I could enhance the expression of c-fos, c-jun mRNA and their proteins, especially the combination of I and Se able to give a remarkable effect on c-jun mRNA expression.
CONCLUSIONS: Se and I may effect the expression of both c-fos and c-jun mRNA, especially the c-jun mRNA and its protein of hippocampus neurons, and thus may effect the differentiation and development of neurons.
Dongping Tian; Min Su; Xianying Wu; Qiaoshan Li; Ruiming Zheng; Guangyuan Li; Tianbao Song; Xiaohu Xu
Related Documents :
18725194 - Thermodynamic analysis of the heterodimerization of leucine zippers of jun and fos tran...
2548844 - The epstein-barr virus early protein eb1 activates transcription from different respons...
18096084 - Fra-1 governs cell migration via modulation of cd44 expression in human mesotheliomas.
16702224 - Cytohesin binder and regulator augments t cell receptor-induced nuclear factor of activ...
17090534 - Wnt-mediated down-regulation of sp1 target genes by a transcriptional repressor sp5.
22159224 - Aberrant cyclin a expression and centrosome overduplication induced by hepatitis b viru...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua bing li xue za zhi Chinese journal of pathology     Volume:  31     ISSN:  0529-5807     ISO Abbreviation:  Zhonghua Bing Li Xue Za Zhi     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0005331     Medline TA:  Zhonghua Bing Li Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Department of Pathology, Shantou University Medical College, Shantou 515031, China (Email:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The expression, characterization and roles of macrophage colony-stimulating factor receptor in human...
Next Document:  The expression of TNF-alpha mRNA and its significance in murine viral myocarditis.