Document Detail


Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.
MedLine Citation:
PMID:  12475444     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To study the effect of selenium (Se) and iodine (I) and the compound of both on the proto-oncogenes c-fos and c-jun mRNA and their protein expression in the cultured rat hippocampus neurons.
METHODS: Using the technique of serum free hippocampus neuron culture, different doses of Se and I and Se + I compound were added into the medium. The expression of the mRNA of c-fos, c-jun in hippocampus neurons cultured for 1, 3, 5, 7 and 10 d were studied using both in situ hybridization and SABC immunohistochemical technique.
RESULTS: Both Se and I could enhance the expression of c-fos, c-jun mRNA and their proteins, especially the combination of I and Se able to give a remarkable effect on c-jun mRNA expression.
CONCLUSIONS: Se and I may effect the expression of both c-fos and c-jun mRNA, especially the c-jun mRNA and its protein of hippocampus neurons, and thus may effect the differentiation and development of neurons.
Authors:
Dongping Tian; Min Su; Xianying Wu; Qiaoshan Li; Ruiming Zheng; Guangyuan Li; Tianbao Song; Xiaohu Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua bing li xue za zhi Chinese journal of pathology     Volume:  31     ISSN:  0529-5807     ISO Abbreviation:  Zhonghua Bing Li Xue Za Zhi     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0005331     Medline TA:  Zhonghua Bing Li Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, Shantou University Medical College, Shantou 515031, China (Email: minsu@ncrc.stu.edu.cn)
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