Document Detail

Effects of selenium and iodine on c-fos and c-jun mRNA and their protein expressions in cultured rat hippocampus cells.
MedLine Citation:
PMID:  12666833     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to investigate the effect of selenium (Se) and iodine (I) for expressions of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus cells in selenium- and iodine-containing medium. With cultured rat hippocampus cells, the different doses of Se and I were added into the medium. The expressions of c-fos/c-jun in cultured rat hippocampus cells (1 d, 3 d, 5 d, 7 d, and 10 d) were studied by using both in situ hybridization histochemistry and SABC immunohistochemistry techniques. Both Se and I could enhance expressions of c-fos and c-jun mRNA and their proteins, especially c-jun mRNA expression in the Se and I united group. Se and I could promote the expressions of c-fos and c-jun and thus may affect the differentiation and development of hippocampus neurons.
Dongping Tian; Min Su; Xiaohu Xu; Xianying Wu; Qiaoshan Li; Rueiming Zheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  90     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2002  
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-86     Citation Subset:  IM    
Department of Pathology, Shantou University Medical College, Guangdong, 515031 China.
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MeSH Terms
Cells, Cultured
Gene Expression Regulation / drug effects*
Genes, fos / genetics
Genes, jun / genetics
Hippocampus / cytology,  drug effects*,  metabolism
Iodine / pharmacology*
Neurons / drug effects,  metabolism
Proto-Oncogene Proteins c-fos / biosynthesis*,  genetics*
Proto-Oncogene Proteins c-jun / biosynthesis*,  genetics*
RNA, Messenger / genetics,  metabolism
Selenium / pharmacology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 7553-56-2/Iodine; 7782-49-2/Selenium

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