Document Detail

Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets.
MedLine Citation:
PMID:  15487769     Owner:  NLM     Status:  MEDLINE    
The hepatic fatty acid metabolism was investigated in rats stressed by selenium deficiency and enhanced fish oil intake. Changes in the composition of lipids, peroxides, and fatty acids were studied in the liver of rats fed either a Sedeficient (8 microg Se/kg) or a Se-adequate (300 microg Se/kg) diet, both rich in n-3 fatty acid-containing fish oil (100 g/kg diet) and vitamin E (146 mg alpha-tocopherol/kg diet). The two diets were identical except for their Se content. Se deficiency led to a decrease in hair coat density and quality as well as to changes in liver lipids, individual lipid fractions and phospholipid fatty acid composition of the liver. The low Se status did reduce total and reduced glutathione in the liver but did not affect the hepatic malondialdehyde level. In liver phospholipids (PL), Se deficiency significantly reduced levels of palmitic acid [16:0], fatty acids of the n-3 series such as DHA [22:6 n-3], and other long-chain polyunsaturates C-20-C-22, but increased n-6 fatty acids such as linoleic acid (LA) [18:2 n-6]. Thus, the conversion of LA to arachidonic acid was reduced and the ratio of n-6/n-3 fatty acids was increased. As in liver PL, an increase in the n-6/n-3 ratio was also observed in the mucosal total fatty acids of the small intestine. These results suggest that in rats with adequate vitamin E and enhanced fish oil intake, Se deficiency affects the lipid concentration and fatty acid composition in the liver. The changes may be related to the decreased levels of selenoenzymes with antioxidative functions. Possible effects of Se on absorption, storage and desaturation of fatty acids were also discussed.
Klaus Schäfer; Antonios Kyriakopoulos; Hildegard Gessner; Tilman Grune; Dietrich Behne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  18     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-18     Completed Date:  2005-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
Institute of Animal Nutrition, Freie Universität Berlin, Berlin, Germany.
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MeSH Terms
Antioxidants / analysis
Body Weight
Dietary Supplements
Fatty Acids / chemistry,  metabolism*
Fish Oils / administration & dosage*,  metabolism
Glutathione / analysis
Glutathione Peroxidase / metabolism
Intestinal Mucosa / chemistry
Liver / chemistry,  metabolism
Malondialdehyde / metabolism
Oxidative Stress
Rats, Wistar
Selenium / chemistry,  deficiency*,  metabolism*
Tissue Extracts / chemistry
alpha-Tocopherol / analysis
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 0/Fish Oils; 0/Tissue Extracts; 542-78-9/Malondialdehyde; 59-02-9/alpha-Tocopherol; 70-18-8/Glutathione; 7782-49-2/Selenium; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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