| Effects of selective and non-selective beta-blockers on the alanine and free fatty acid responses to glucagon challenge in hemodialysis patients. | |
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MedLine Citation:
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PMID: 2879659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoglycemia is frequently reported in hemodialysis patients on propranolol. The effects of beta-blockers on the glucose, alanine and free fatty acid responses to glucagon challenge (2 mg) in fourteen hemodialysis patients were studied. Patients on propranolol had impaired glycemic response while those on metoprolol had decreased response only before dialysis. There was a significant negative correlation between propranolol level (log-transformed) and glycemic responses, suggesting that propranolol has direct effect on the latter. Hemodialysis patients had fasting alanine levels comparable to those of normal subjects. After glucagon challenge, the decrements in alanine level had no consistent relationship to the impaired glycemic response. Thus suppression of gluconeogenesis is unlikely to be the prime cause of propranolol-induced hypoglycemia. The basal free fatty acid levels were significantly lower among hemodialysis patients on propranolol. This limited availability of free fatty acid as well as the inhibitory effect on hepatic glucagon-stimulated glucose output may contribute to the predisposition to hypoglycemia in dialysis patients given propranolol. The results suggest that metoprolol has less interference on energy substrate supply in hemodialysis patients under fasting conditions. |
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Authors:
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K K Pun; C K Yeung; W Chak; P W Ho; M K Chan; H J Lin; R T Yeung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 26 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-03-13 Completed Date: 1987-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 222-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Adult Alanine / blood* Blood Glucose / analysis Fatty Acids, Nonesterified / blood* Glucagon / diagnostic use* Humans Metoprolol / analogs & derivatives, pharmacology Middle Aged Propranolol / pharmacology Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 37350-58-6/Metoprolol; 525-66-6/Propranolol; 56-41-7/Alanine; 56392-16-6/alpha-hydroxymetoprolol; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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