Document Detail

Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells.
MedLine Citation:
PMID:  14750029     Owner:  NLM     Status:  MEDLINE    
Tissue damage as a result of oxygen radical generation may be involved in the pathogenesis of different diseases, carcinogenesis, aging and cell death. The inhibition of the proliferation rate of the immortalised human cell line ECV 304 after oxidant damage by oxygen radicals generated in a hypoxanthine-xanthine oxidase system and the protection provided by some selected flavone and flavonol glycosides as well as by caffeic acid and its derivatives was determined. The cytotoxicity of the reactive oxygen species was differentially influenced by selected flavonoids and seems to be determined by the pattern of substitution and by their lipophilicity. Apigenin and quercetin demonstrated the strongest effect on the inhibition of hypoxanthine-xanthine oxidase-induced toxicity (50 % restitution of the cells at a concentration of 0.36 microM and 3.1 microM, respectively). The beneficial effect of the flavonol glycosides rutin and hyperoside was weak, whereas flavone glycosides such as diosmin showed a better effect of protection.
Gabriele Beyer; Matthias F Melzig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  69     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-29     Completed Date:  2004-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1125-9     Citation Subset:  IM    
Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
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MeSH Terms
Caffeic Acids / administration & dosage,  pharmacology*,  therapeutic use
Cell Line / drug effects
Cell Survival / drug effects*
Flavonoids / administration & dosage,  pharmacology*,  therapeutic use
Free Radical Scavengers / administration & dosage,  pharmacology*,  therapeutic use
Hypoxanthine / diagnostic use
Plants, Medicinal*
Xanthine Oxidase / diagnostic use
Reg. No./Substance:
0/Caffeic Acids; 0/Flavonoids; 0/Free Radical Scavengers; 331-39-5/caffeic acid; 68-94-0/Hypoxanthine; EC Oxidase

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