Document Detail

Effects of sedation with detomidine hydrochloride on echocardiographic measurements of cardiac dimensions and indices of cardiac function in horses.
MedLine Citation:
PMID:  8933067     Owner:  NLM     Status:  MEDLINE    
Twenty-six horses were sedated with detomidine hydrochloride (Domosedan, SmithKline Beecham Animal Health, Tadworth, Surrey, UK) at a dose of 10 micrograms/kg bwt, administered i.v. Echocardiograms were recorded before and after sedation, measurements of cardiac dimensions were made and functional indices were calculated. The pre- and post sedation values were compared. No significant change was detected following sedation in the ejection time (ET), left ventricular dimension, left atrial diameter at the sinotubular junction at end-systole or end-diastole or at the sinus of Valsalva at end-diastole. Sedation was found to result in a statistically significant increase in end-systolic left ventricular diameter and internal area and aortic diameter measured at the sinus of Valsalva. Left ventricular free-wall thickness and interventricular septal thickness at end-systole, fractional shortening, fractional area change and heart rate were significantly reduced following sedation. A significant increase in pre-ejection period (PEP), duration of electromechanical systole (EMS) and PEP/ET (ejection time) was detected.
M W Patteson; C Gibbs; P R Wotton; P J Cripps
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1997-02-03     Completed Date:  1997-02-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Department of Clinical Veterinary Science, University of Bristol, Avon, UK.
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MeSH Terms
Cardiovascular Physiological Phenomena
Cardiovascular System / drug effects
Diastole / physiology
Echocardiography / methods,  veterinary*
Heart / anatomy & histology*,  drug effects,  physiology*
Horses / anatomy & histology*,  physiology*
Hypnotics and Sedatives / pharmacology*
Imidazoles / pharmacology*
Sinus of Valsalva / anatomy & histology,  physiology,  ultrasonography
Systole / physiology
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Imidazoles; 76631-46-4/detomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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