| Effects of secretin on extracellular amino acid concentrations in rat hippocampus. | |
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MedLine Citation:
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PMID: 15206007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 1998, Horvath et al. (1998) observed a marked improvement in speech, eye contact, and attention in autistic children five weeks after treatment with secretin, which ocurred in the course of an endoscopic investigation. Since autism is hypothesized to be a hypoglutamatergic disorder we investigated the in vivo effects of secretin on extracellular amino acids in the rat brain. Studies were carried out on freely moving rats with microdialysis probes in the hippocampus. Amino acids were examined using tandem mass spectroscopy and HPLC/fluorometric detection. Following secretin injection (8.7 microg/kg i.p.), considerable increases in microdialysate glutamate and gamma-aminobutyric acid (GABA) levels were observed; other amino acids were not affected. The observed increased microdialysate concentrations of glutamate and GABA following secretin application may explain the results of the Horvath study. |
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Authors:
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A Kuntz; H-W Clement; W Lehnert; D van Calker; K Hennighausen; M Gerlach; E Schulz |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-02-04 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 111 ISSN: 0300-9564 ISO Abbreviation: J Neural Transm Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-18 Completed Date: 2004-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 931-9 Citation Subset: IM |
Affiliation:
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Department of Child and Adolescent Psychiatry, University Children's Hospital, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Extracellular Fluid / drug effects*, metabolism Hippocampus / drug effects*, metabolism Male Microdialysis / statistics & numerical data Rats Rats, Inbred Lew Secretin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 1393-25-5/Secretin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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