Document Detail


Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans.
MedLine Citation:
PMID:  16982099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: During the Gulf War (GW), in early March 1991, a munitions dump at Khamisiyah, Iraq, was destroyed. Later, in 1996, the dump was found to have contained the organophosphate chemical warfare agents, sarin and cyclosarin. METHODS: Data collected in a study conducted between 1994 and 1996, before the Khamisiyah incident was publicly disclosed, were used to examine neurobehavioral task performances of GW veterans (n=140) categorized as having received high, moderate, or low-to-no exposure dose levels to sarin and cyclosarin at Khamisiyah, Iraq. Exposure levels were based on modeled estimates of the exposure plume and on troop location information at the time of the Khamisiyah event. Based on recent findings observed in follow-up studies of persons exposed to sarin during the 1995 terrorist attacks in Japan, we hypothesized that exposure to sarin and cyclosarin would be associated with poorer performances on objective neurobehavioral tasks in specific functional domains (particularly in visuospatial abilities and psychomotor functioning) in a dose-dependent manner. RESULTS: Sarin and cyclosarin exposure was significantly associated with less proficient neurobehavioral functioning on tasks involving fine psychomotor dexterity and visuospatial abilities 4-5 years after exposure. CONCLUSIONS: Findings suggest a dose-response association between low-level exposure to sarin and cyclosarin and specific functional central nervous system effects 4-5 years after exposure.
Authors:
Susan P Proctor; Kristin J Heaton; Tim Heeren; Roberta F White
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-08-07
Journal Detail:
Title:  Neurotoxicology     Volume:  27     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  931-9     Citation Subset:  IM    
Affiliation:
Boston Environmental Hazards Center, VA Boston Healthcare System, Boston, MA 02130-4893, USA. sproctor@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Attention / drug effects
Chemical Warfare Agents / toxicity*
Dose-Response Relationship, Drug
Environmental Exposure*
Female
Gulf War*
Humans
Linear Models
Male
Mental Processes / drug effects*
Middle Aged
Neuropsychological Tests / statistics & numerical data
Organophosphorus Compounds / toxicity*
Psychomotor Performance / drug effects
Retrospective Studies
Sarin / toxicity*
United States
Veterans
Chemical
Reg. No./Substance:
0/Chemical Warfare Agents; 0/Organophosphorus Compounds; 107-44-8/Sarin; 329-99-7/cyclohexyl methylphosphonofluoridate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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