| Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole. | |
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MedLine Citation:
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PMID: 18824069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Locomotor sensitization induced by the dopamine agonist quinpirole can be potentiated by co-treatment with the synthetic kappa opioid agonist U69593. The identification of salvinorin A, an active component of the psychotropic sage Salvia divinorum, as a structurally different agonist of kappa-opioid receptors raised the question of whether this compound would similarly potentiate sensitization to quinpirole. Rats were co-treated with 0.5 mg/kg quinpirole and either salvinorin A (0.04, 0.4 or 2.0 mg/kg) or U69593 (0.3 mg/kg). Control groups were co-treated with vehicle and saline, vehicle and quinpirole (0.5 mg/kg), or saline and salvinorin A (0.4 mg/kg). Rats were injected biweekly for a total of 10 injections and locomotor activity measured after each treatment. Results showed that the highest dose of salvinorin A potentiated sensitization to quinpirole as did U69593, the middle salvinorin A dose had no effect on quinpirole sensitization, and the lowest dose of salvinorin A attenuated sensitization to quinpirole. These findings indicate that structural differences between salvinorin A and U69593 do not affect the potentiation of quinpirole sensitization. Moreover, the opposite effects of high and low salvinorin A doses suggest that salvinorin A can produce bidirectional modulation of sensitization to dopamine agonists. |
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Authors:
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Pieter Beerepoot; Vincent Lam; Alice Luu; Bernice Tsoi; Daniel Siebert; Henry Szechtman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 446 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-28 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 101-4 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology Animals Benzeneacetamides / pharmacology Central Nervous System / drug effects*, metabolism Diterpenes, Clerodane / pharmacology* Dopamine / metabolism Dopamine Agents / pharmacology Dopamine Agonists / pharmacology* Dose-Response Relationship, Drug Drug Interactions / physiology Drug Resistance / drug effects, physiology Drug Synergism Male Motor Activity / drug effects*, physiology Pyrrolidines / pharmacology Quinpirole / pharmacology* Rats Rats, Long-Evans Receptors, Dopamine D2 / agonists*, metabolism Receptors, Dopamine D3 / agonists* Receptors, Opioid, kappa / agonists, metabolism Synaptic Transmission / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Benzeneacetamides; 0/Diterpenes, Clerodane; 0/Dopamine Agents; 0/Dopamine Agonists; 0/Pyrrolidines; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; 0/Receptors, Opioid, kappa; 83729-01-5/salvinorin A; 85760-74-3/Quinpirole; 96744-75-1/U 69593 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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