| Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 19262499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness. |
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Authors:
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Jihong Hu; Xiongjing Jiang; Nicole Li; Xuequn Yu; Vlado Perkovic; Bailing Chen; Liancheng Zhao; Bruce Neal; Yangfeng Wu |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-02-27 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 32 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 282-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle Brachial Index Blood Pressure / physiology Cardiovascular Diseases / diet therapy*, physiopathology* China Diet, Sodium-Restricted* Double-Blind Method Female Hemodynamics / physiology Humans Male Middle Aged Regional Blood Flow / physiology Risk Factors Rural Population Sodium, Dietary* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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