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Effects of salt loading on sympathetic activity and blood pressure in anesthetized two-kidney, one clip hypertensive rats.
MedLine Citation:
PMID:  22117829     Owner:  NLM     Status:  In-Data-Review    
In this study, we investigated the effects of salt loading on sympathetic pressor activity, cardiac autonomic activity, mean arterial pressure (MAP), heart rate (HR) and on the relations between them in anesthetized two-kidney, one clip (2K1C) hypertensive rats. We submitted rats to either renal artery clipping or sham operation. Distilled water or 0.5 % NaCl was given orally to the clipped and sham-operated control rats for 4 weeks. Then, MAP and HR differences between pre- and post- autonomic blockade were evaluated as indexes of sympathetic pressor and cardiac autonomic activity, respectively. The autonomic blockade decreased MAP to the similar levels in all groups (between 81.7±7.6 -87.3±7.1 mmHg). Sympathetic pressor activity was greater in the clipped rats than in its sham-operated controls only under salt loading (55.3±6.2 vs. 37.0±4.1 mmHg, p<0.05). Cardiac autonomic activity was, predominantly, sympathetic and more in the clipped group than in the sham-operated rats under distilled water (48.3±8.6 vs. 19.7±7.0 beats/min, p<0.05) but not under salt loading. Salt loading inverted the relationship between HR and cardiac autonomic activity in 2K1C hypertensive rats (r=-0.76, p=0.046 vs. r=0.89, p=0.019). These results suggest that salt loading may have augmented the effect of renovascular constriction on MAP by affecting the sympathetic pressor activity and the relation between cardiac autonomic activity and HR in 2K1C hypertensive rats.
Besim Ozaykan; Ayşe Doğan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences     Volume:  11     ISSN:  1840-4812     ISO Abbreviation:  Bosn J Basic Med Sci     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200947     Medline TA:  Bosn J Basic Med Sci     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, University of Çukurova, Mithat Özsan Bulvarı, 01330 Balcalı, Adana, Turkey.
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