Document Detail

Effects of salinomycin on cell-mediated immunity of broiler chickens against hydropericardium syndrome and Newcastle disease viruses.
MedLine Citation:
PMID:  19096061     Owner:  NLM     Status:  MEDLINE    
The effects of salinomycin (SAL) on protective cell-mediated immune (CMI) responses of vaccinated and challenged broiler chicks against hydropericardium syndrome virus (HPSV) and Newcastle disease (NDV) were investigated while comparing 3 reference drugs [levamisole, cyclophosphamide (CYP), and cyclosporine (CYS)]. Peripheral lymphoproliferation, skin hypersensitivity reactions, and the ability of chicks to resist virulent HPSV and virulent NDV challenges were used to determine the effects of drugs on CMI responses in chicks. Salinomycin-medicated chicks showed significant (P < 0.05) stimulation of lymphoproliferation and nonsignificant (P > 0.05) stimulation of skin hypersensitivity reactions compared with untreated control chicks. However, skin thickness and lymphoproliferation of SAL-medicated chicks were significantly greater (P < 0.05) than those of CYP- and CYS-treated chicks. The greatest survival rate was recorded in SAL-medicated chicks compared with immune-suppressed (CYP- and CYS-treated) and untreated control chicks after virulent NDV and virulent HPSV challenges. Thus, it was concluded that SAL had beneficial effects on the CMI responses of broiler chicks against HPSV and NDV.
K Munir; M A Muneer; A Tiwari; E Masaoud; R M Chaudhry
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  88     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
Lahore Veterinary Diagnostic Laboratories, Shadman, Lahore-54000, Pakistan.
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MeSH Terms
Adjuvants, Immunologic / pharmacology
Cyclophosphamide / pharmacology
Cyclosporine / pharmacology
Immunity, Cellular / drug effects*
Immunosuppressive Agents / pharmacology
Ionophores / pharmacology
Levamisole / pharmacology
Newcastle Disease / immunology,  prevention & control*
Pericardial Effusion / immunology,  prevention & control,  veterinary*
Pyrans / pharmacology*
Time Factors
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunosuppressive Agents; 0/Ionophores; 0/Pyrans; 14769-73-4/Levamisole; 50-18-0/Cyclophosphamide; 53003-10-4/salinomycin; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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