Document Detail


Effects of salbutamol and glyceryl trinitrate on large arterial stiffness are similar between patients with hypertension and adults with normal blood pressure.
MedLine Citation:
PMID:  16822279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Endothelial function is characteristically impaired in patients with hypertension. Endothelial function was assessed in men and women with hypertension using a recently described, non-invasive method. METHODS: Twenty patients and 20 controls received salbutamol 400 microg and glyceryl trinitrate (GTN) 500 microg in a two-way randomized, single-blind study. Effects on augmentation index (AIx) were assessed using pulse wave analysis (PWA). RESULTS: Responses (absolute AIx reduction and 95% confidence interval) to salbutamol were 8.4% (6.2, 10.6) and 8.3% (7.0, 9.6) in patients and controls, respectively, and those to GTN were 13.6% (10.8, 16.4) and 15.5% (13.0, 17.0), respectively. CONCLUSIONS: Systemic arterial responses to endothelium-dependent and -independent vasodilators are preserved in patients with mild, uncomplicated hypertension, indicating normal large arterial endothelial function.
Authors:
W Stephen Waring; Hannah M Sinclair; David J Webb
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-07-06
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  62     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2007-03-29     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  621-6     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology Unit, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK. s.waring@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / therapeutic use*
Adult
Albuterol / therapeutic use*
Arteries / drug effects,  physiopathology*
Blood Pressure / drug effects*
Female
Humans
Hypertension / drug therapy*
Male
Middle Aged
Nitroglycerin / therapeutic use*
Vasodilator Agents / therapeutic use*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Vasodilator Agents; 18559-94-9/Albuterol; 55-63-0/Nitroglycerin
Comments/Corrections

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