Document Detail

Effects of rosiglitazone on cardiac function in CAPD patients: a tissue Doppler study.
MedLine Citation:
PMID:  19839823     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Insulin resistance was an independent predictor of cardiovascular mortality in uremic patients without diabetes. Rosiglitazone (ROS) improves insulin sensitivity in the liver, muscle, and adipose tissue. We prospectively investigated the effects of ROS on cardiac functions by standard (SDE) and tissue Doppler echocardiography (TDI) in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: A total of 24 CAPD patients (13 males, 11 females; mean age 42.2 +/- 14.8 years) were included. Routine blood samples were examined. Left and right ventricular functions were assessed, and myocardial performance index (MPI) was calculated by SDE and TDI at baseline and after 12-month ROS therapy. Left and right atrial volumes were measured and indexed to body surface area. RESULTS: When compared with baseline, after 12 months of ROS treatment, it was shown that early (E) and late (A) diastolic velocities of atrioventricular valves, E/A ratio, mitral E-wave deceleration time (DT), isovolumetric relaxation time (IVRT), and MPI were similar (p > 0.05). Also, no significant changes were detected in LV dimensions, LV mass index, LVEF, LA volume index, or RA volume index measured by SDE before and after ROS therapy (p > 0.05). Left and right ventricular function parameters measured by TDI including Sm, Em, Am, Em/Am ratio, E/Em ratio, and MPI were similar. CONCLUSION: It was found that there was no negative effect of long-term ROS therapy on cardiac functions measured by SDE and TDI in CAPD patients.
Ahmet Akcay; Gurkan Acar; Abdullah Sokmen; Gulizar Sokmen; Ekrem Dogan; Hayriye Sayarlioglu; Cagatay Citirik; Mehmet Ali Ucar; Cemal Tuncer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  31     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  464-9     Citation Subset:  IM    
Faculty of Medicine, Department of Cardiology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
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MeSH Terms
Blood Flow Velocity
Cohort Studies
Echocardiography, Doppler, Pulsed / methods*
Heart Function Tests
Kidney Failure, Chronic / diagnosis,  mortality,  therapy
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory / adverse effects,  methods*
Prospective Studies
Reference Values
Risk Assessment
Survival Analysis
Thiazolidinediones / administration & dosage*
Treatment Outcome
Vasodilator Agents / administration & dosage*
Ventricular Dysfunction, Left / drug therapy*,  mortality,  ultrasonography
Ventricular Dysfunction, Right / drug therapy*,  mortality,  ultrasonography
Reg. No./Substance:
0/Thiazolidinediones; 0/Vasodilator Agents; 122320-73-4/rosiglitazone

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