Document Detail

Effects of rocuronium and vecuronium on intracranial pressure, mean arterial pressure and heart rate in neurosurgical patients.
MedLine Citation:
PMID:  8957976     Owner:  NLM     Status:  MEDLINE    
We have evaluated the effects of a single bolus dose of rocuronium 0.6 mg kg-1 (group 1, n = 10) or vecuronium 0.1 mg kg-1 (group 2, n = 10) on intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP) and heart rate (HR) in 20 neurosurgical patients undergoing mechanical ventilation of the lungs during continuous sedation with sufentanil and midazolam. Before and after neuromuscular block using twice the ED90 of the blockers, ICP, MAP, CPP and HR were recorded continuously for 15 min. Treatment caused no significant changes in ICP, CPP or MAP and there was no evidence of histamine release. Mean maximum block in the rocuronium group was slightly less than that in the vecuronium group (95.9 (3.1)% vs 100%; ns) The difference between the two groups in onset time (rocuronium 142 (62) s, vecuronium 192 (64) s; P = 0.04) was significant. Patients in the rocuronium group showed a slight (7(4)%) but significant (P = 0.003) increase in heart rate.
W M Schramm; K Strasser; A Bartunek; H Gilly; C K Spiss
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  77     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  IM    
Department of Anaesthesia and General Intensive Care, University of Vienna, Austria.
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MeSH Terms
Androstanols / pharmacology*
Blood Pressure / drug effects
Cerebrovascular Circulation / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Intracranial Pressure / drug effects*
Middle Aged
Neuromuscular Nondepolarizing Agents / pharmacology*
Neurosurgical Procedures*
Vecuronium Bromide / pharmacology
Reg. No./Substance:
0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium; 50700-72-6/Vecuronium Bromide
Comment In:
Br J Anaesth. 1997 Mar;78(3):342   [PMID:  9135327 ]

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