| Effects of risperidone on event-related potentials in schizophrenic patients. | |
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MedLine Citation:
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PMID: 11302567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to examine the effects of risperidone on cognitive impairment in schizophrenia, event-related potentials (ERPs) were recorded before and after switching from conventional neuroleptics to risperidone in schizophrenic patients. ERPs were recorded during two auditory discrimination tasks (an oddball task and a distraction task) in 10 medicated schizophrenic patients during conventional neuroleptic and risperidone treatments. The amplitudes and latencies of N 100 and P300 component were measured in ERPs for target stimuli in the oddball task and in ERPs for target and novel stimuli in the distraction task. Although N 100 amplitude and latency and P 300 amplitude did not change significantly after switching the drug compared to that during conventional neuroleptic treatment, P 300 latency for target stimuli shortened significantly during risperidone treatment in both tasks, accompanied by the shortening of the reaction time in the distraction task. The P 300 latency change did not correlate with the change of the severity of psychopathology. These findings suggest that risperidone may speed the information processing in schizophrenic patients, contributing to the improvement of cognitive functions. |
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Authors:
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A Iwanami; Y Okajima; H Isono; J Shinoda; K Kasai; A Hata; M Fukuda; K Nakagome; K Kamijima |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 34 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-13 Completed Date: 2001-08-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: Germany |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan. iwanami-tky@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / pharmacology*, therapeutic use Attention / drug effects Event-Related Potentials, P300 / drug effects* Female Humans Male Reaction Time / drug effects, physiology Risperidone / pharmacology*, therapeutic use Schizophrenia / drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 106266-06-2/Risperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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