| Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. | |
| | |
MedLine Citation:
|
PMID: 17668223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rikkunshito (TJ-43), a herbal medicine consisting of eight herbs, is used to treat chronic dyspepsia. Studies have shown that TJ-43 improves human gastric emptying. This study investigated the effects of TJ-43 on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux (GER). Eight children, aged from 2 months to 15 years (median age 4 years), were studied. Six of them had neurological impairment. TJ-43 (0.3 g/kg/day) was given orally or via nasogastric tubes in three divided doses before meals for 7 days. Their symptoms were frequent emesis in four, nausea in two, and hematemesis and stridor in one each. Twenty-four-hour esophageal pH monitoring was conducted using multichannel pH electrodes located at the distal esophagus (P1) and 10 cm proximal to P1 (P2). The clinical symptoms and esophageal pH were compared before and after TJ-43 therapy for 1 week. The frequency of emesis decreased in three patients. Other symptoms, including nausea, hematemesis, and stridor, were relieved in the remaining patients. Measured at the distal pH electrode, the percentage time of esophageal pH < 4.0 and the mean duration of reflux decreased significantly (P < 0.05). However, the number of acid reflux per hour did not change significantly, and no pH parameters measured at the proximal electrode differed significantly. The short-term administration of TJ-43 relieved symptoms and reduced the distal esophageal acid exposure through improved esophageal acid clearance. |
| | |
Authors:
|
Hisayoshi Kawahara; Akio Kubota; Toshimichi Hasegawa; Hiroomi Okuyama; Takehisa Ueno; Shinobu Ida; Masahiro Fukuzawa |
Related Documents
:
|
582703 - Correlation between the plasma concentration of free nicotinic acid and some of its pha... 6402373 - Abnormal tryptophan pyrrolase and amino acids related to melanogenesis in vitiligo. 3387963 - Effects of exposure to freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric surgery international Volume: 23 ISSN: 0179-0358 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-18 Completed Date: 2008-01-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 1001-5 Citation Subset: IM |
Affiliation:
|
Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka, Japan, 594-1101. kawahara@mch.pref.osaka.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Drugs, Chinese Herbal
/
pharmacology*,
therapeutic use Esophagus / drug effects* Gastroesophageal Reflux / drug therapy* Gastrointestinal Agents / pharmacology*, therapeutic use Gastrointestinal Motility / drug effects* Humans Hydrogen-Ion Concentration |
| Chemical | |
Reg. No./Substance:
|
0/Drugs, Chinese Herbal; 0/Gastrointestinal Agents; 0/liu-jun-zi-tang |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal diagnostic clue for fetus in fetu.
Next Document: Biochemical identification of bovine spongiform encephalopathies in cattle.