Document Detail


Effects of right stellate ganglion stimulation on regional myocardial blood flow and ischemic injury in dogs.
MedLine Citation:
PMID:  7250188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of right stellate ganglion stimulation (RSGS) on regional myocardial blood flow (RMBF) and epicardial ST-segment elevation were investigated in the normal and ischemic myocardium of anesthetized dogs. In the non-ischemic areas and despite the augmentation of cardiac work resulting from the increase in heart rate and in myocardial contractile force, RSGS induced no significant changes in RMBF or in the endo/epi ratio. However, after suppression by atenolol of its chronotropic and inotropic effects, RSGS significantly increased the calculated coronary resistance and reduced RMBF, and combined atenolol + phenoxybenzamine treatments abolished these effects. In the ischemic areas, RSGS had no effect on RMBF, endo/epi and I/NI ratios but increased ST-segment elevation, an effect abolished by atenolol. We conclude that (1) during RSGS, alpha-adrenoreceptor-mediated coronary vasoconstriction contributes to oppose beta 1-myocardial stimulation effects on RMBF and endo/epi ratio, (2) further elevation of ST-segment by RSGS is due to enhancement of oxygen requirements by beta 1-adrenoreceptor stimulation.
Authors:
F Tato; A Berdeaux; J P Vilaine; J F Giudicelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  71     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  223-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atenolol / pharmacology
Coronary Circulation*
Coronary Disease / physiopathology*
Dogs
Electric Stimulation
Electrocardiography
Female
Heart / innervation*
Hemodynamics
Male
Myocardial Contraction
Oxygen Consumption
Receptors, Adrenergic / physiology
Stellate Ganglion / physiology*
Vagotomy
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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